The Louisville Cardinals take on the Virginia Tech Hokies in Blacksburg, Virginia. Kickoff is set for 3 p.m. ET on The CW.
Louisville is favored by 10.5 points on the spread with a moneyline of -400. Virginia Tech, meanwhile, enters as a +10.5 favorite and is +320 on the moneyline to pull off the upset. The over/under sits at 53.5 total points.
Here's my Louisville vs. Virginia Tech prediction and college football picks for Saturday, November 1.
Louisville vs Virginia Tech Prediction
- Louisville vs. Virginia Tech Pick: Over 53.5
My Virginia Tech vs. Louisville best bet is on both teams to go over the total. Find the best line available on our live NCAAF odds page.
Louisville vs Virginia Tech Odds
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10.5 -110 | 53.5 -110o / -110u | -400 |
| Virginia Tech Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10.5 -110 | 53.5 -110o / -110u | +320 |
- Louisville vs Virginia Tech Spread: Louisville -10.5, Virginia Tech +10.5
- Louisville vs Virginia Tech Over/Under: 53.5 Points
- Louisville vs Virginia Tech Moneyline: Louisville -400, Virginia Tech +320
Louisville vs Virginia Tech College Football Betting Preview
Louisville Cardinals Betting Preview: Offense Set to Soar
Louisville has been one of the biggest risers this season, entering ranked 16th in the country and two weeks removed from taking down Miami on the road.
The Cardinals have given USC transfer Miller Moss the keys to the offense, and he has done nothing but thrive.
Moss ranks 41st in completion percentage and 70th in yards per pass. He has limited turnovers and should continue to pad his stats in a great matchup this week.
Virginia Tech's secondary is a big issue, as it ranks 127th in opponent completion percentage and 119th in yards per pass allowed.
The Hokies have also struggled to get off the field, ranking 98th in opponent third-down conversion rate and 133rd in opponent red-zone scoring rate.
Those two stats point to plenty of points for a Louisville offense that's already averaging 31.8 per game.
Virginia Tech Hokies Betting Preview: All Eyes on Drones
The Hokies were a team I faded last week, and they proved me wrong by not only surviving Cal but covering the spread in double overtime.
They did so with a relentless rushing attack, as Marcellous Hawkins and Kyron Drones combined for 304 yards on the ground.
However, Drones stepped up, accounting for 35 of Virginia Tech's 42 points, throwing three touchdowns and running for two more. However, this week, he and the rest of the Hokies offense will be put to the test.
Louisville's defense has been the backbone of its team, ranking 20th in yards per pass allowed and 18th in yards per rush.
As we know, the ground game is essential for the Hokies offensively, and they sit 24th in yards per rush with a relatively high volume of attempts.
However, our angle may rely on the arm of Drones, who's shown flashes but has been very ineffective through the air overall. It'll be interesting to see if the Hokies can continue to use their home-field advantage and get the offense rolling early.
Louisville vs Virginia Tech Pick, Betting Analysis
Much like how I saw Cal's offense last week, Louisville is in a tremendous spot offensively to dictate this matchup.
With such a huge advantage through the air, we should see the Cardinals post a big number on the scoreboard while the Hokies battle to keep this matchup within two scores.
Take the over.
Pick: Over 53.5 (Play to 54.5)
Louisville vs Virginia Tech Betting Trends
