The Missouri State Bears take on the Kennesaw State Owls in Kennesaw, Georgia. Kickoff is set for 2:00 p.m. EST on ESPN+.
Kennesaw State is favored by 6.5 points on the spread with a moneyline of -240. The total is set at 57 points.
Here’s my Missouri State vs. Kennesaw State prediction and college football picks for Saturday, November 22, 2025.
Missouri State vs Kennesaw State Prediction
- Missouri State vs. Kennesaw State Pick: Missouri State ML (+195, bet365)
My Kennesaw State vs. Missouri State best bet is on the Bears ML. Find the best line available on our live NCAAF odds page.
Missouri State vs Kennesaw State Odds
| Missouri St Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 57 -110o / -110u | +195 |
| Kennesaw St Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 57 -110o / -110u | -240 |
- Missouri State vs Kennesaw State point spread: Kennesaw State -6.5 (-110), Missouri State +6.5 (-110)
- Missouri State vs Kennesaw State over/under: 57 (-110o / -110u)
- Missouri State vs Kennesaw State moneyline: Missouri State +195, Kennesaw State -240
Missouri State vs Kennesaw State Game Preview
This game activated one of our Action PRO betting systems, powered by Evan Abrams.
In college football, contrarian underdogs thrive when the betting line moves against them.
When spreads shift by several points from open to close, it often reflects heavy public or sharp money fading the dog, inflating the line, and creating hidden value on the moneyline.
In games where the spread is moderate to large, between four and just over 13, these underdogs are often overlooked but capable of outright wins.
The inflated perception of the favorite can lead to mispriced odds, and the contrarian angle looks to capitalize on those rare moments when the market has overcorrected.
This system has been profitable in the long term, but teams that fit the system this season are 33-55 outright, with a 36% win rate generating a 29% ROI.
Missouri State vs Kennesaw State Pick
The Owls opened as a four-point favorite, but the line has since moved toward a touchdown.
That said, this game feels like a complete toss-up.
Both teams are 7-3 and 5-1 in conference play.
By Net Success Rate, these teams are about dead even (Missouri State -4.8%, Kennesaw State -4.3%). By Net EPA per Play, the Bears are actually the slightly stronger team (Bears -0.04, Owls -0.08).
Both of these teams create explosives at top-10 rates nationally while struggling to prevent explosives.
The most significant difference between these two teams is that Missouri State relies on the pass while Kennesaw State relies on the run.
Regardless, my point is that this game feels like a coin flip, with both squads having an even chance of moving to 6-1 in conference play.
Even when accounting for Missouri State's home-field advantage (worth about 2.5 points, per Collin Wilson), I still think the Bears are worth taking a shot on at nearly 2-to-1 odds.
Pick: Missouri State ML (+195, bet365)
