The Nevada Wolf Pack take on the Wyoming Cowboys in Laramie, Wyoming. Kickoff is set for 2:00 p.m. EST on MW Network.
Wyoming is favored by 6.5 points on the spread with a moneyline of -260. The total is set at 40.5 points.
Here’s my Nevada vs. Wyoming prediction and college football picks for Saturday, November 22, 2025.
Nevada vs Wyoming Prediction
- Nevada vs. Wyoming Pick: Nevada +6.5 (-110, bet365)
My Wyoming vs. Nevada best bet is on the Wolf Pack to cover. Find the best line available on our live NCAAF odds page.
Nevada vs Wyoming Odds
| Nevada Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 40.5 -110o / -110u | +210 |
| Wyoming Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 40.5 -110o / -110u | -260 |
- Nevada vs Wyoming point spread: Wyoming -6.5 (-110), Nevada +6.5 (-110)
- Nevada vs Wyoming over/under: 40.5 (-110o / -11ou)
- Nevada vs Wyoming moneyline: Nevada +210, Wyoming -260
Nevada vs Wyoming Preview
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
Bounce Back Fade is a college football system that capitalizes on public overreaction to teams coming off a poor performance.
In conference play, when an opponent has just lost by more than three points and enters with only a one-game home or away streak, bettors often expect a strong rebound effort.
Oddsmakers know this tendency and may shade the line toward that team, creating hidden value on the other side.
By focusing on spreads between three and 16 points, the system captures games that are competitive enough for the line to matter but not so close that small swings decide the outcome.
In these situations, fading the supposed bounce-back team has historically delivered consistent returns, as motivation alone does not erase underlying weaknesses that caused the initial loss.
Can Wyoming bounce back after back-to-back demoralizing losses against Fresno State (24-3) and San Diego State (24-7)?
The system doubts that.
The 4-6 Pokes aren't that good. Although Nevada is similarly pathetic, the Pack are catching nearly a touchdown in a game where the total has barely cracked 40.
Pick: Nevada +6.5 (-110, bet365)
