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Chiefs vs. Bills Odds & Betting Predictions - November 27, 2026

Chiefs at Bills

1:20 am • NBC/Peacock

Kansas City Chiefs

6-2
@

Buffalo Bills

7-1

Chiefs at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Chiefs
6-2
N/A
N/A
N/A
Bills
7-1
N/A
N/A
N/A
location pinFriday 1:20 a.m.
November 27, 2026
Highmark StadiumOrchard Park

Chiefs vs. Bills Props

Prop Projections

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Chiefs vs. Bills Public Betting Percentages

Away Logo

Chiefs

Public

Home Logo

Bills

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Bills are 4-1 in their last 5 games.
  • Bills are 4-1 in their last 5 games against the spread
  • Bills are 3-1 in their road games against the spread
  • The totals have gone OVER in 3 of Bills' last 5 games
  • The totals have gone OVER in 2 of Bills' 4 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills		6-23-13-15-21-0
Chiefs		4-43-11-34-20-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills		5-32-23-14-31-0
Chiefs		3-51-32-22-41-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills		7-1N/AN/A6-11-0
Chiefs		6-2N/AN/A6-00-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 10th@MINW 23-6-3.5 WU 46BUF -192
Nov 1stBALW 36-10-3 WU 55BUF -175
Oct 18th@LVW 33-30-5.5 LO 54.5BUF -235
Oct 13th@LAW 37-34+3.5 WO 55.5BUF +150
Oct 4thNEL 26-29-7 LO 49.5NE -350

Bills vs. Chiefs Injury Updates

Bills Injuries

  • Joshua Palmer
    WR

    Palmer is out with hamstring

    Out

Chiefs Injuries

  • Patrick Mahomes
    QB

    Mahomes is questionable with elbow

    Questionable

  • Tyquan Thornton
    WR

    Thornton is out with ankle

    Out

  • Xavier Worthy
    WR

    Worthy is questionable with hamstring

    Questionable

  • Brashard Smith
    RB

    Smith is out with hamstring

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Josh Allen logo
    Josh Allen
    2027
    pyds
  • passing touchdowns
    Josh Allen logo
    Josh Allen
    12
    ptd
  • rushing yards
    James Cook logo
    James Cook
    814
    ryds
  • rushing touchdowns
    Josh Allen logo
    Josh Allen
    9
    rtd
Depth Charts
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Starter2ND3RD4TH
QBJosh AllenKyle AllenShane Buechele
RBJames CookTy JohnsonRay DavisFrank Gore
WRKhalil ShakirStephen Gosnell
TEDalton KincaidDawson KnoxJackson HawesKeleki Latu
LTDion DawkinsJude BowryChase Lundt
LGAlec AndersonAustin Corbett
CConnor McGovernLloyd Cushenberry
RGO'Cyrus TorrenceAr'maj Reed-Adams
RTSpencer BrownTylan Grable
LDET.J. SandersLandon Jackson
WLBDorian WilliamsKaleb Elarms-Orr
MLBTerrel BernardKeonta JenkinsJoe Andreessen
LCBChristian BenfordDavison Igbinosun
SSDamar HamlinJalon Kilgore
FSCole BishopGeno StoneSam Franklin
RCBMaxwell HairstonKani Walker
PTommy Doman
HTommy Doman
PRKhalil ShakirKeon ColemanSkyler Bell
KRRay DavisTy JohnsonSkyler Bell
LSReid Ferguson
LOLBGreg RousseauMichael HoechtMike Danna
ROLBBradley ChubbTJ ParkerJavon SolomonAndre Jones
DTEd OliverZane Durant
NTDeone Walker
RWRDJ MooreSkyler BellJa'Mori Maclin
NBDee AlfordJordan HancockTe'Cory Couch
KTyler Bass
LWRKeon ColemanJoshua PalmerTrent Sherfield
Team Stats

Passing

1971
YDS
1918
177/263
Comps/Atts
156/236
7.745
YPA
8.589
14/4
TDs/INTs
12/6
11/66
Sacks/Yards
17/109

Rushing

1102
Rush Yards
1173
217
Attempts
261
5.078
YPC
4.494
10
TDs
17

Turnovers

Fumbles Lost
4
Interceptions
6

Efficiency

19/30 63.33%
Redzone
22/33 66.67%
40/96 0%
3rd Down
41/95 0%
8/14 0%
4th Down
8/10 0%

First Downs

166
Total
189
94
Pass
93
61
Rush
76
11
Penalty
20

Misc

/
Penalties/Yards
/
Possession

Chiefs vs. Bills Odds Comparison

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Chiefs at Bills Team Totals

MatchupOverUnder
Chiefs
6-2
N/A
N/A
Bills
7-1
N/A
N/A