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Falcons vs. Cardinals Odds & Betting Predictions - December 21, 2025

Falcons at Cardinals

9:05 pm • FOX

Atlanta Falcons

4-8
@

Arizona Cardinals

3-9

Falcons at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Falcons
4-8
N/A
N/A
N/A
Cardinals
3-9
N/A
N/A
N/A
location pinSunday 9:05 p.m.
December 21, 2025
State Farm StadiumGlendale

Falcons vs. Cardinals Props

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Falcons vs. Cardinals Public Betting Percentages

Away Logo

Falcons

Public

Home Logo

Cardinals

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Cardinals are 1-4 in their last 5 games.
  • Cardinals are 3-2 in their last 5 games against the spread
  • Cardinals are 5-1 in their road games against the spread
  • The totals have gone OVER in 2 of Cardinals' last 5 games
  • The totals have gone OVER in 5 of Cardinals' 6 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals		6-61-55-11-25-4
Falcons		6-62-33-31-55-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals		7-55-12-42-15-4
Falcons		5-72-32-43-32-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals		3-9N/AN/A2-11-8
Falcons		4-8N/AN/A1-53-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 30th@TBL 17-20+4.5 WU 45.5TB +185
Nov 23rdJACL 24-27+2.5 LO 47.5JAC +114
Nov 16thSFL 22-41+3.5 LO 48.5SF +157
Nov 9th@SEAL 22-44+7.5 LO 44.5SEA +285
Nov 4th@DALW 27-17+3.5 WU 53.5ARI +145

Falcons vs. Cardinals Injury Updates

Falcons Injuries

  • Drake London
    WR

    London is out with knee

    Out

  • Michael Penix
    QB

    Penix is out with knee

    Out

Cardinals Injuries

  • Zay Jones
    WR

    Jones is out with achilles

    Out

  • James Conner
    RB

    Conner is out with foot

    Out

  • Kyler Murray
    QB

    Murray is out with foot

    Out

  • Emari Demercado
    RB

    Demercado is out with ankle

    Out

  • Trey Benson
    RB

    Benson is out with knee

    Out

  • Tip Reiman
    TE

    Reiman is out with ankle

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Jacoby Brissett logo
    Jacoby Brissett
    2188
    pyds
  • passing touchdowns
    Jacoby Brissett logo
    Jacoby Brissett
    13
    ptd
  • rushing yards
    Bam Knight logo
    Bam Knight
    255
    ryds
  • rushing touchdowns
    Bam Knight logo
    Bam Knight
    4
    rtd
Depth Charts
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Starter2ND3RD4TH
QBKyler MurrayJacoby Brissett
RBJames ConnerTrey BensonEmari DemercadoMichael CarterZonovan Knight
WRGreg DortchZay JonesAndre Baccellia
TETrey McBrideTip ReimanElijah HigginsTravis VokolekJosiah Deguara
LTParis JohnsonKelvin Beachum
LGEvan Brown
CHjalte FroholdtJon Gaines
RGIsaiah AdamsWill HernandezHayden Conner
RTJonah WilliamsChristian JonesJosh FryarJeremiah Byers
LDECalais CampbellWalter NolenL.J. Collier
RDEDarius RobinsonJustin JonesBilal Nichols
WLBAkeem Davis-GaitherOwen Pappoe
MLBMack WilsonCody SimonJ.J. Russell
LCBWill JohnsonElijah Jones
SSJalen ThompsonDadrion Taylor-Demerson
FSBudda BakerJoey BlountKitan Crawford
RCBMax MeltonDenzel Burke
PBlake Gillikin
HBlake Gillikin
PRGreg DortchXavier Weaver
KRGreg DortchAndre Baccellia
LSAaron Brewer
LWRMarvin HarrisonSimi FehokoTejhaun Palmer
NTDalvin TomlinsonDante StillsPJ Mustipher
ROLBJosh SweatBJ Ojulari
KChad Ryland
RWRMichael WilsonXavier Weaver
LOLBBaron BrowningZaven CollinsJordan BurchElliott Brown
NBGarrett WilliamsKei'Trel ClarkDarren Hall
Team Stats

Passing

2529
YDS
2840
235/384
Comps/Atts
315/465
6.94
YPA
6.77
12/4
TDs/INTs
19/7
19/136
Sacks/Yards
42/308

Rushing

1487
Rush Yards
1207
330
Attempts
280
4.506
YPC
4.311
14
TDs
9

Turnovers

Fumbles Lost
4
Interceptions
7

Efficiency

22/34 64.71%
Redzone
27/47 57.45%
47/142 0%
3rd Down
70/163 0%
9/19 0%
4th Down
7/18 0%

First Downs

235
Total
248
129
Pass
156
84
Rush
70
22
Penalty
22

Misc

/
Penalties/Yards
/
Possession

Falcons vs. Cardinals Odds Comparison

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Falcons at Cardinals Team Totals

MatchupOverUnder
Falcons
4-8
N/A
N/A
Cardinals
3-9
N/A
N/A