The Atlanta Falcons (5-9) and Arizona Cardinals (3-11) squre off in NFL Week 16 on Sunday, Dec. 21. Kickoff is set for 4:05 p.m. ET from State Farm Stadium in Glendale, Ariz. The game will be broadcast live on FOX.
The Falcons are 3-point favorites over the Cardinals on the spread (Falcons -3), with the over/under set at 48 total points. Atlanta is a -160 favorite to win outright, while Arizona is +135 to pull off the upset.
Let's get into my Falcons vs Cardinals predictions.
- Falcons vs Cardinals pick: Cardinals Moneyline (+135)
My Falcons vs Cardinals best bet is the Arizona moneyline. Find the best odds by checking our live NFL odds page.
Falcons vs Cardinals Odds
| Falcons Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3 -105 | 48 -110o / -110u | -160 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3 -115 | 48 -110o / -110u | +135 |
Falcons vs Cardinals NFL Week 16 Preview
The Cardinals haven't had the chance to get many wins at home so far this season.
Arizona has drawn tough matchups on its home turf against the Packers, Seahawks, 49ers, and Jaguars throughout the year — the Cardinals' most winnable home game resulted in a disastrous 22-21 loss to the Titans.
Their track record at home aside, this still might be a good time to buy low on the Cardinals. Arizona's last six games have consisted of matchups against the Texans, Rams, Buccaneers, Jaguars, 49ers, and Seahawks — all teams that are very much alive in the NFC playoff race.
However, the Cardinals may finally get a chance to catch their breath this week with Kirk Cousins and the 5-9 Falcons coming to town.
Falcons vs Cardinals Prediction, Betting Analysis
I expect Bijan Robinson to perform in this game, but I think the Cardinals’ offense can hang with the Falcons, who could be prime for a letdown spot after an upset win over the Buccaneers a week ago. Atlanta had lost seven of its last eight games before Kirk Cousins and Kyle Pitts turned into Tom Brady and Rob Gronkowski on TNF.
Marvin Harrison Jr.'s status is one to monitor entering this game. His presence — along with Trey McBride and Michael Wilson — would be a boon to pass-happy Jacoby Brissett.
Pick: Cardinals Moneyline (+135)
Spread
I'm targeting the Cardinals moneyline instead of the spread in this game.
Moneyline
My Cardinals vs Falcons betting prediction is on Arizona to win outright on the moneyline.
Over/Under
I'm passing on the game total.



















