49ers vs. Cardinals Odds & Betting Predictions - November 16, 2025

49ers at Cardinals

9:05 pm • FOX

San Francisco 49ers

@

Arizona Cardinals

MatchupOpenSpreadTotalMoneyline
49ers 5-2	N/A	N/A	N/A
Cardinals 2-5	N/A	N/A	N/A

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Sunday 9:05 p.m.

November 16, 2025

State Farm StadiumGlendale

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NFL Public Betting

Cardinals are 1-4 in their last 5 games.
Cardinals are 3-2 in their last 5 games against the spread
Cardinals are 3-0 in their road games against the spread
The totals have gone OVER in 2 of Cardinals' last 5 games
The totals have gone OVER in 3 of Cardinals' 4 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	4-3	1-3	3-0	1-2	3-1
49ers	4-3	1-2	3-1	2-2	2-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	4-3	3-1	1-2	2-1	2-2
49ers	4-3	1-2	3-1	2-2	2-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	2-5	N/A	N/A	2-1	0-4
49ers	5-2	N/A	N/A	3-1	2-1

date	opponent	score	spread	over/under	moneyline
Oct 19th	GB	L 23-27	+7 W	O 44.5	GB +270
Oct 12th	@IND	L 27-31	+8.5 W	O 46.5	IND +350
Oct 5th	TEN	L 21-22	-7.5 L	O 41.5	TEN -420
Sep 26th	SEA	L 20-23	+1.5 L	U 43.5	SEA +102
Sep 21st	@SF	L 15-16	+1.5 W	U 44.5	SF +105

Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Brock Purdy
QB
Purdy is out with toe
Out
Ricky Pearsall
WR
Pearsall is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Jordan James
RB
James is doubtful with finger
Doubtful

James Conner
RB
Conner is out with foot
Out
Kyler Murray
QB
Murray is out with foot
Out
Owen Pappoe
LB
Pappoe is questionable with quad
Questionable
Emari Demercado
RB
Demercado is out with ankle
Out
Trey Benson
RB
Benson is out with knee
Out
Tip Reiman
TE
Reiman is out with ankle
Out

See more NFL Injuries

passing yards
Kyler Murray
962
pyds
passing touchdowns
Kyler Murray
6
ptd
rushing yards
Kyler Murray
173
ryds
rushing touchdowns
Bam Knight
2
rtd

	Starter	2ND	3RD	4TH
QB	Kyler Murray	Jacoby Brissett
RB	James Conner	Trey Benson	Emari Demercado	Michael Carter	Bam Knight
WR	Greg Dortch	Zay Jones	Andre Baccellia
TE	Trey McBride	Tip Reiman	Elijah Higgins	Travis Vokolek	Josiah Deguara
LT	Paris Johnson	Kelvin Beachum
LG	Evan Brown	Nick Leverett
C	Hjalte Froholdt	Jon Gaines
RG	Isaiah Adams	Will Hernandez	Hayden Conner
RT	Jonah Williams	Christian Jones	Josh Fryar	Jeremiah Byers
LDE	Calais Campbell	Walter Nolen	L.J. Collier	Anthony Goodlow
RDE	Darius Robinson	Justin Jones	Bilal Nichols
WLB	Akeem Davis-Gaither	Owen Pappoe
MLB	Mack Wilson	Cody Simon	J.J. Russell
LCB	Will Johnson	Elijah Jones
SS	Jalen Thompson	Dadrion Taylor-Demerson
FS	Budda Baker	Joey Blount	Kitan Crawford
RCB	Max Melton	Denzel Burke
P	Blake Gillikin
H	Blake Gillikin
PR	Greg Dortch	Xavier Weaver
KR	Greg Dortch	Andre Baccellia
LS	Aaron Brewer
RWR	Michael Wilson	Xavier Weaver	Bryson Green
LWR	Marvin Harrison	Simi Fehoko	Tejhaun Palmer
ROLB	Josh Sweat	BJ Ojulari	Xavier Thomas
K	Chad Ryland
LOLB	Baron Browning	Zaven Collins	Jordan Burch	Elliott Brown
NB	Garrett Williams	Kei'Trel Clark	Darren Hall
NT	Dalvin Tomlinson	Dante Stills	PJ Mustipher

Total

Passing

1899

YDS

1399

178/267

Comps/Atts

162/242

7.453

YPA

6.45

10/8

TDs/INTs

10/4

14/91

Sacks/Yards

24/162

Rushing

667

Rush Yards

773

200

Attempts

175

3.335

YPC

4.417

3

TDs

5

Turnovers

Fumbles Lost

8

Interceptions

4

Efficiency

11/23 47.83%

Redzone

15/27 55.56%

48/101 0%

3rd Down

43/96 0%

6/10 0%

4th Down

4/7 0%

First Downs

155

Total

133

100

Pass

80

43

Rush

38

12

Penalty

15

Misc

/

Penalties/Yards

/

Possession

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MatchupOverUnder
49ers 5-2	N/A	N/A
Cardinals 2-5	N/A	N/A