49ers vs. Cardinals Odds & Betting Predictions - November 16, 2025
49ers at Cardinals
9:05 pm • FOX49ers at Cardinals Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() 49ers 5-2 | N/A | N/A | N/A | |
![]() Cardinals 2-5 | N/A | N/A | N/A |

State Farm StadiumGlendale
49ers vs. Cardinals Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Cardinals Public Betting Percentages
Betting Trends
- Cardinals are 1-4 in their last 5 games.
- Cardinals are 3-2 in their last 5 games against the spread
- Cardinals are 3-0 in their road games against the spread
- The totals have gone OVER in 2 of Cardinals' last 5 games
- The totals have gone OVER in 3 of Cardinals' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Cardinals Injury Updates

49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Brock PurdyQB
Purdy is out with toe
Out
- Ricky PearsallWR
Pearsall is out with knee
Out
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan JamesRB
James is doubtful with finger
Doubtful

Cardinals Injuries
- James ConnerRB
Conner is out with foot
Out
- Kyler MurrayQB
Murray is out with foot
Out
- Owen PappoeLB
Pappoe is questionable with quad
Questionable
- Emari DemercadoRB
Demercado is out with ankle
Out
- Trey BensonRB
Benson is out with knee
Out
- Tip ReimanTE
Reiman is out with ankle
Out
Player Stats
- passing yardsKyler Murray962pyds
- passing touchdownsKyler Murray6ptd
- rushing yardsKyler Murray173ryds
- rushing touchdownsBam Knight2rtd
Depth Charts
Starter | 2ND | 3RD | 4TH | ||
---|---|---|---|---|---|
QB | Kyler Murray | Jacoby Brissett | |||
RB | James Conner | Trey Benson | Emari Demercado | Michael Carter | Bam Knight |
WR | Greg Dortch | Zay Jones | Andre Baccellia | ||
TE | Trey McBride | Tip Reiman | Elijah Higgins | Travis Vokolek | Josiah Deguara |
LT | Paris Johnson | Kelvin Beachum | |||
LG | Evan Brown | Nick Leverett | |||
C | Hjalte Froholdt | Jon Gaines | |||
RG | Isaiah Adams | Will Hernandez | Hayden Conner | ||
RT | Jonah Williams | Christian Jones | Josh Fryar | Jeremiah Byers | |
LDE | Calais Campbell | Walter Nolen | L.J. Collier | Anthony Goodlow | |
RDE | Darius Robinson | Justin Jones | Bilal Nichols | ||
WLB | Akeem Davis-Gaither | Owen Pappoe | |||
MLB | Mack Wilson | Cody Simon | J.J. Russell | ||
LCB | Will Johnson | Elijah Jones | |||
SS | Jalen Thompson | Dadrion Taylor-Demerson | |||
FS | Budda Baker | Joey Blount | Kitan Crawford | ||
RCB | Max Melton | Denzel Burke | |||
P | Blake Gillikin | ||||
H | Blake Gillikin | ||||
PR | Greg Dortch | Xavier Weaver | |||
KR | Greg Dortch | Andre Baccellia | |||
LS | Aaron Brewer | ||||
RWR | Michael Wilson | Xavier Weaver | Bryson Green | ||
LWR | Marvin Harrison | Simi Fehoko | Tejhaun Palmer | ||
ROLB | Josh Sweat | BJ Ojulari | Xavier Thomas | ||
K | Chad Ryland | ||||
LOLB | Baron Browning | Zaven Collins | Jordan Burch | Elliott Brown | |
NB | Garrett Williams | Kei'Trel Clark | Darren Hall | ||
NT | Dalvin Tomlinson | Dante Stills | PJ Mustipher |
Team Stats
1899
YDS
1399
178/267
Comps/Atts
162/242
7.453
YPA
6.45
10/8
TDs/INTs
10/4
14/91
Sacks/Yards
24/162
11/23 47.83%
Redzone
15/27 55.56%
48/101 0%
3rd Down
43/96 0%
6/10 0%
4th Down
4/7 0%
49ers vs. Cardinals Odds Comparison
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49ers at Cardinals Team Totals
MatchupOverUnder | ||
---|---|---|
![]() 49ers 5-2 | N/A | N/A |
![]() Cardinals 2-5 | N/A | N/A |