Bills vs. Rams NFL Odds Week 1: Thursday Night’s Season Opener Attracting Wiseguy Action

Bills vs. Rams NFL Odds Week 1: Thursday Night’s Season Opener Attracting Wiseguy Action article feature image

Photo by Ian Johnson/Icon Sportswire via Getty Images. Pictured: Los Angeles Rams head coach Sean McVay

  • Bills vs. Rams NFL odds for Thursday night's season-opening matchup have been on the move thanks to sharp betting action.
  • With the Bills vs. Rams spread and over/under settling in ahead of Thursday night's kickoff, the betting value devil is in the details of how these odds have moved since opening in May.
  • With this in mind, let's take a deeper look at the latest Bills vs. Rams odds, including how smart money from professional bettors is shaping these lines.

Bills vs. Rams NFL Odds

Bills Odds-2.5
Rams Odds+2.5
DateThursday, Sept. 8
Time8:20 p.m. ET

*Odds as of Thursday morning

Sports fans across the globe will be tuning in on Thursday night as the Buffalo Bills visit the reigning Super Bowl champion Los Angeles Rams to kickoff the 2022-23 NFL season.

Well, most sports fans will because months ago a certain author of this article bought show tickets for him and his wife, not realizing it was also the same night as the Bills vs. Rams NFL kickoff game.


But that doesn't mean I'm not interested in betting Bills vs. Rams, because, contrary to popular belief, you can actually wager on games that you won't be watching.

At first glance though, Bills vs. Rams doesn't look all that interesting from a betting market perspective, especially when comparing opening to current odds.

However, it's important to remember that NFL odds for Week 1 have been available since May, so it's even more crucial to dig into line histories for these games in order to truly decipher the positions that respected bettors are taking.

And after doing just that, I quickly picked up on the sneaky position that wiseguys are taking for Bills vs. Rams on Thursday night.

Bills vs. Rams NFL Pick

The latest Bills vs. Rams total is sitting essentially where it opened almost four months ago.

But as I mentioned above, it has already gone on quite the ride.