Cardinals vs. 49ers Betting Odds, Picks & Predictions
Isaiah J. Downing-USA TODAY Sports. Pictured: Jimmy Garoppolo
- We cover every actionable angle of the Arizona Cardinals at San Francisco 49ers, complete with odds and picks.
Cardinals at 49ers Odds, Picks & Predictions
- Odds: 49ers -10
- Over/Under: 44
- Kickoff: 4:05 p.m. ET
- TV Channel: FOX
Our analysts and experts break down the most important angles of this game.
Here’s an excerpt, but you can read the full story here.
The Cardinals almost upset the 49ers two weeks ago, losing 28-25 at home.
While the Niners have the second-best defense in the league, they’ve been vulnerable against the run. In their 27-24 loss to Seattle, they allowed 147 yards at 4.3 yards per carry.
More importantly, the Cardinals gashed the 49ers in their first meeting for a total of 153 rushing yards and an average of 6.7 yards per carry. The newly-acquired Kenyan Drake rushed for 110 yards at 7.3 yards per carry.
Besides Drake, the Cardinals will also benefit from the return of David Johnson, who has four weeks of RB10 performances or better.
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