Cardinals vs. 49ers Betting Odds, Picks & Predictions

Cardinals at 49ers Odds, Picks & Predictions

• Odds: 49ers -10
• Over/Under: 44
• Kickoff: 4:05 p.m. ET
• TV Channel: FOX

Our analysts and experts break down the most important angles of this game.

Here's an excerpt, but you can read the full story here.

The Cardinals almost upset the 49ers two weeks ago, losing 28-25 at home.

While the Niners have the second-best defense in the league, they’ve been vulnerable against the run. In their 27-24 loss to Seattle, they allowed 147 yards at 4.3 yards per carry.

More importantly, the Cardinals gashed the 49ers in their first meeting for a total of 153 rushing yards and an average of 6.7 yards per carry. The newly-acquired Kenyan Drake rushed for 110 yards at 7.3 yards per carry.

Besides Drake, the Cardinals will also benefit from the return of David Johnson, who has four weeks of RB10 performances or better.

See our full betting breakdown for Cardinals-49ers.

Our Experts' Week 11 Picks

Our staff breaks down how they're betting 1 and 4 p.m. ET games. See their picks.

Pick 'Em Confidence Rating

Sean Koerner ranks every straight-up and against-the-spread pick for pools in his Pick 'Em Confidence Ratings. You can even create custom ATS ratings based on the specific spreads your league is using.

See where the Cardinals and 49ers rank.

Survivor Pool Recommendations

Ten weeks down. Seven to go. Should you roll with either team in Week 11? Our NFL simulations reveal the best survivor pool picks.

Week 11 Fantasy Football Rankings

Our trio of experts are obsessively updating their fantasy football rankings so you can set your lineups with confidence. Here's how they rank QBs, RBs, WRs, TEs and Flex players for PPR, standard and half PPR leagues.