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The Arizona Cardinals (1-2) and New York Giants (2-1) will clash in Week 4 of the NFL season this afternoon. Kickoff is set for 1:00 p.m. ET from MetLife Stadium in East Rutherford, N.J. The game will broadcast live on CBS.
The Cardinals are 2.5-point favorites over the Giants on the spread, with the over/under set at 43.5 total points. Arizona is a -136 moneyline favorite to win outright, while New York is a +116 underdog to pull off the upset.
Let's get into my Cardinals vs Giants predictions for Sunday, October 4.
My Cardinals vs Giants Prediction
- Cardinals vs Giants pick: Over 43.5 (-118)
My Cardinals vs. Giants best bet is the total to go Over 43.5 points, with the best price currently available at FanDuel. Make sure to find the best odds by checking our live NFL odds page.
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Cardinals vs Giants Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 43.5 -118o / -104u | -136 |
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 43.5 -118o / -104u | +116 |
Cardinals vs Giants NFL Week 4 Preview
Arizona Cardinals Betting Preview: Surprisingly Competent Offense
The Cardinals' offense has played crisp, efficient football behind Jacoby Brissett.
Brissett provides a high floor of competency, distributing the ball effectively to Arizona's dynamic skill players. He routinely peppers star tight end Trey McBride, who has 33 targets through three games.
Rookie running back Jeremiyah Love is also coming off the best game of his young career after he rushed for 90 yards and scored a receiving touchdown against the 49ers.
The Cardinals shouldn't have much trouble moving the ball against a heavily compromised New York defensive unit.
New York Giants Betting Preview: The Jameis Winston Experience
The Giants' season was thrown into chaos when Jaxson Dart went down, forcing Jameis Winston into the starting lineup.
The Jameis experience typically leads to high-variance fireworks; he loves to aggressively push the ball downfield and force tight-window throws. He played things pretty conservatively in the rain last week against Tennessee, but the Giants likely won't be able to tame the beast two weeks in a row.
To make matters worse, Giants edge rusher Brian Burns is out, leaving a pass rush that generated just three pressures on Cam Ward last week completely neutered.
Cardinals vs Giants Prediction, Betting Analysis
Sharps out here in Vegas are already betting this Over, causing the line to cross key numbers.
Without Brian Burns generating pressure, Jacoby Brissett should be able to sit comfortably in the pocket and pick apart a banged-up Giants secondary.
Meanwhile, Jameis Winston will likely push the pace and sling it downfield for the Giants. Expect a fast-paced, high-scoring shootout.
Pick: Over 43.5 (-118)
Cardinals vs Giants Betting Trends
Cardinals Trends
- The Cardinals are 6-1 ATS against the NFC East over the last five seasons.
Giants Trends
- Jameis Winston is 17-6 to the Over in October in his career (since 2015).
- Jacoby Brissett and Jameis Winston have faced off just once in their careers. The O/U was 46.5 and the Colts and Bucs combined for 72 points that day.
