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49ers vs. Packers NFL Betting Predictions, Picks: The Top Model Edge for the Divisional Round Playoffs

49ers vs. Packers NFL Betting Predictions, Picks: The Top Model Edge for the Divisional Round Playoffs article feature image
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Photo by Justin Casterline/Getty Images. Pictured: Head coach Kyle Shanahan of the San Francisco 49ers

  • Saturday's NFL playoff Divisional Round is anchored by San Francisco 49ers vs. Green Bay Packers at 8:15 p.m. ET.
  • Green Bay temperatures will be frigid, which could result in a big home-field advantage for the Packers at Lambeau Field.
  • However, thanks to our NFL betting model predictions and picks, we don't have to guess, so let's look at the big 49ers vs. Packers edge.

49ers vs. Packers Odds

49ers Odds +5.5
Packers Odds -5.5
Over/Under 47.5
Date Saturday, Jan. 22
Time 8:15 p.m. ET
TV FOX

*Odds as of Saturday morning

Aaron Rodgers and the Green Bay Packers are exactly where they want to be.

Sure, the San Francisco 49ers are no easy out and have been a thorn in Green Bay’s side in the past, but the Pack are at home on Saturday night and will be playing in extremely cold weather conditions in which Rodgers has historically exceled.

In addition, the Packers are currently 5.5-point favorites over the 49ers, which is the largest spread of the four NFL Playoffs Divisional Round matchups.

While the path is there for Green Bay to advance to another NFC Championship Game, there’s still a 5.5-point spread for bettors to cover.

And speaking of bettors, how should they approach 49ers vs. Packers on Saturday night?

Will Kyle Shanahan’s team overcome its injuries and keep this game close? Or will the Pack leverage home-field advantage into a relatively easy cover for their backers?

Let’s break down our NFL betting model’s 49ers vs. Packers edge, which also happens to the biggest edge of the Divisional Round.

49ers vs. Packers Prediction