Our Favorite Packers vs. 49ers Sunday Night Football Betting Picks on the Spread & Over/Under

Packers at 49ers Betting Picks

• Odds: 49ers -3
• Over/Under: 48
• Kickoff: 8:20 p.m. ET
• TV Channel: NBC

Odds as of Sunday afternoon.

There's a lot at stake on Sunday Night Football.

If the San Francisco 49ers win, they would maintain control of the top spot in the NFC, boosting their chances of earning the No. 1 seed to 49.46% according to our Bet Labs model.

If the Green Bay Packers win, they would overtake the lead and double their chances of finishing with the top seed to 38.26%.

So which team are our experts betting on to cover? Is there any betting value on the total?

Let's take a look at two picks on the spread and over/under.

Matthew Freedman: Packers +3

Aaron Rodgers off the bye is 8-1-1 against the spread (per Bet Labs), and the Packers are as healthy as any team in the league. They have every starter available for the game.

The 49ers are rather injured. Joe Staley is out. Dee Ford is out. Matt Breida and kicker Robbie Gould are technically doubtful but aren't expected to play. And George Kittle, Emmanuel Sanders and Deebo Samuel are questionable — they'll probably play, but all of them are likely to be physically limited.

The Packers and 49ers have similar records, but the Packers have played a much tougher schedule, with wins over quality opponents in the Vikings, Cowboys, Raiders and Chiefs. Meanwhile the 49ers have victories over just one quality opponent: The disappointing Rams.

I wouldn't bet the Packers past +3, but I do like them at that number.

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Sean Koerner: Under 48

Both teams are likely to lean on their running game on Sunday night. And the 49ers have been vulnerable on the ground on late, which makes it likely the Packers attack them with Aaron Jones and Jamaal Williams.

On the other side of the ball, Sanders is still dealing with a nagging rib injury and Kittle could miss his third straight game due to his knee injury, which will likely force the 49ers to lean on their running game more as a result. (Both are listed as questionable as of Sunday morning.)

The 49ers are the 25th ranked team in terms of pace of play while the Packers are 31st, so it's more likely this matchup favors the environment for the under.