There's also one key matchup that's very worrying for San Francisco: Seattle's run game. Klint Kubiak is the new play caller in Seattle, and if preseason is any indication, his presence could transform this Seahawks rushing attack. A young offensive line that was widely panned as consensus bottom-three in the league suddenly looked outstanding, and Seattle was ripping off big runs left and right. San Francisco's pass defense was good last season, but the 49ers ranked bottom 10 by DVOA against the run and entire the season with a gaping hole at defensive tackle. The 49ers allowed the 5th most fantasy points to opposing RBs last season, letting 10 RBs rush for 70+ yards and giving up a league-high 18 rushing TDs to opposing RBs. Kenneth Walker looks healthy and should get plenty of touches in Kubiak's system. He had a touchdown in both 49ers games last fall. Let's back Walker to go over 59.5 yards, and as a slight escalator, we'll place a portion of our bet on Walker going over his rushing line and also finding the endzone at +323 (FanDuel).