Rams vs. 49ers Betting Odds, Predictions & Picks (December 21, 2019)

Rams vs. 49ers Betting Odds, Predictions & Picks (December 21, 2019) article feature image

Rams vs. 49ers Betting Odds

  • Rams Spread: +7
  • 49ers Spread: -7
  • Rams Moneyline: +270
  • 49ers Moneyline: -330
  • Over/Under: 45.5
  • Time: 8:15 p.m. ET, NFL Network
For real-time odds, go to the Rams-49ers game page to find the best price to bet.


The San Francisco 49ers are a favorite against the Los Angeles Rams in Week 16 of the 2019 NFL season.

Here are the betting trends, statistics, model predictions and picks you need to help wager on it.

Rams vs. 49ers Model Prediction

The 49ers have a 68% chance of winning this game, according to our NFL model. The true point spread is the 49ers -6.5, giving slight value to Los Angeles. The over/under in our model is projected at 44.8, giving slight value to the under.

Statistical Matchup

The 49ers are averaging 0.19 more yards per play than the Rams this season.

  • Los Angeles Rams are 6-4 ATS in the last 10 games
  • San Francisco 49ers are 5-4-1 ATS in the last 10 games

Betting Percentage Breakdown

As of December 21st, 37% of bets are on the Rams +7.

The game total is 45.5 and 69% of bets are on the over.

Get real-time betting percentages for every NFL game here.

Rams vs. 49ers Betting Picks

  • Justin Bailey: Under 45.5
  • YBK Picks.com: 49ers -7
  • John Ewing: 49ers -6.5
  • Matt Moore: 49ers -6.5
  • Danny Donahue: Rams moneyline +271
  • Danny Donahue: Rams +7
  • 256 or Bust: Under 45
  • The Vegas Refund : Rams +7
  • Sean Zerillo: Rams +7
  • Sean Zerillo: Under 45
  • Stuck : Under 45

Rams vs. 49ers Player Props Picks

These are the prop bets that have been officially logged in The Action Network App by our experts:

Sean Koerner

  • Tyler Higbee under 5 receptions
  • Brandin Cooks under 3 receptions

Matthew Freedman

  • Brandin Cooks under 33.5 receiving yards
  • Josh Reynolds under 18.5 receiving yards

Sean Zerillo

  • Tyler Higbee under 5 receptions
  • Brandin Cooks under 33.5 receiving yards
  • Brandin Cooks under 3 receptions

How would you rate this article?