The Giants (1-0) and Rams (0-1) meet tonight on Monday Night Football. Kickoff is set for 8:15 p.m. ET from SoFi Stadium in Inglewood, California. The game will broadcast live on ESPN and ABC.
Giants vs Rams odds (via FanDuel) list the Rams as -300 favorites on the moneyline and the Giants as +245 underdogs. The over/under is 47.5 (-105o / -115u). The Rams are 6.5-point favorites on the spread over the Giants (Rams -6.5; -115).
Below you can find my Giants vs Rams predictions — plus the latest odds, Matthew Stafford prop, inactives, and betting trends.
Giants vs Rams Predictions, Pick
- Giants vs Rams pick: Rams -6.5 (-115)
My Giants vs. Rams best bet is Los Angeles to cover the spread (-6.5), with the best price currently available at DraftKings. Make sure to find the best odds by checking our live NFL odds page.
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Giants vs Rams Odds
| Giants Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+6.5 -105 | 47.5 -105o / -115u | +245 |
| Rams Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-6.5 -115 | 47.5 -105o / -115u | -300 |
Giants vs Rams Preview
Giants Preview
This is a difficult game to handicap due to the uncertainty surrounding the status of Puka Nacua. He's one of the best receivers in the league and obviously a complete game-changer. He would impact the spread, total, and player props.
We still don't know if Nacua will give it a go, but it was reported he was trending in the wrong direction on Sunday, hence why this spread has moved in the Giants' favor.
It's also worth mentioning that fellow wide receiver Jordan Whittington won't play due to injury, so the Rams would be very thin at the WR position if Nacua can't go.
That's welcome news for the Giants, who have a very suspect cornerback room that is also dealing with a number of injuries. In one of this game's bigger mismatches on paper, New York could catch a huge break with a shorthanded LA wide receiver corps.
Reigning defensive player of the year Myles Garrett also won't play, but Aaron Donald is slated to make his season debut. What will we get from the future hall-of-famer? Tough to say, adding another layer of uncertainty here.
Rams Preview
The Rams looked completely lifeless in Australia last week, but I am refusing to overreact to a bizarre international travel spot.
Sometimes, you have to react to what you see in Week 1 (Chargers, clearly), but sometimes those are just outlier performances (ex. Broncos missing every tackle in KC).
At least LA flew in the day before the game and immediately flew out, meaning their bodies never even adjusted to the time change.
Now, the Rams are back home on Monday Night Football with extended rest, which has proven valuable in the past following Week 1 where I think adjustments are worth a bit more, especially with preseason playing time for starters decreasing with each passing year. Just take a look at the Seahawks, Patriots, and 49ers yesterday.
If you had told me before the season that I could lay seven points with the Rams at home against the Giants, I would have sprinted to the window.
The Nacua and Garrett injuries throw a wrench into that, but I'm still going to trust the Rams at under a touchdown to cover in a prime buy low-sell high spot.
Even without Nacua, McVay can go with heavy personnel and destroy a bad Giants run defense, which should set up easy play-action passes for Stafford, who can stay ahead of the chains and avoid the ferocious New York pass rush in obvious passing situations.
Giants vs Rams Against the Spread Pick
This is the classic Week 2 overreaction game. Look, you have to give credit to the Giants for their effort against Dallas, but I think a lot of that had to do with a brand-new (and underprepared) Dallas defense that just didn't know what to expect from a new-look Giants offense.
I loved the use of Patrick Ricard and Isaiah Likely for the Giants, who almost looked like a quasi-service academy team. They want to be physical and bleed clock, which does fit this team well with a mobile quarterback in Jaxson Dart and the bruising Cam Skattebo in the backfield. It's a feisty, fun bunch.
But, the Rams do at least know what to expect and have demonstrated many times before they can defend power run games, even with lighter boxes — and if they can do that on early downs, their secondary and pass rush should have the edge over New York's wide receivers and offensive line.
Two weeks ago, nobody was buying the Giants, while simultaneously crowning the Rams as a super team. But now, one weird trip to Australia (against a very good SF squad) and a Giants win over a poorly prepared Dallas defense has the market completely overreacting, in my opinion.
I expect the Rams to bring their absolute best effort (FWIW, McVay has been nails ATS following a loss at 63%).
Unless the Giants can maintain their touchdown rate on their clock-bleeding possessions, the Rams can still easily win this by two-possessions even without Nacua — and if Nacua can play, I'm not sure how the Giants get any stops.
I'd also look at the Under, but this is definitely a tough game to handicap, so I wouldn't go crazy with anything until we know more.
Pick: Rams -6.5 (-115)
Giants vs Rams Props: Fade Stafford?
By Sean Koerner
I expect the Rams to lean on their run game tonight with Puka Nacua's status in question. They registered a ridiculous -12.3% PROE in the opener — there’s no way I’m projecting them to be that run heavy again, but I’m still only around +2% PROE tonight.
When Matthew Stafford does throw, I expect those passes to be downfield looks to Davante Adams and Terrance Ferguson. The wide receiver depth behind Nacua is quite thin.
Jordan Whittington, who would’ve been the most natural short-area replacement, is doubtful with a quad injury. Konata Mumpfield could inherit that role, but I don’t expect Stafford to pepper him with targets. Xavier Smith, Tutu Atwell and CJ Daniels all profile more as downfield/big-play options.
With this prop, we’re living well with Stafford primarily completing deep passes. A 20+ yard completion advances the ball quickly, shortens the drive and puts the Rams in position to score. A long TD is even better because the drive ends immediately and a Rams lead encourages more rushing.
The Giants should be run heavy themselves with Greg Roman influencing their offense, which can keep Stafford standing on the sideline and lower the overall play volume. I think both teams could approach this game in a way that naturally suppresses total snaps, and completion props are directly tied to that.
I have Stafford closer to 20.8 completions with around a 58% chance to stay under 21.5, but I think a lot of the underlying factors lean even more toward the under than that raw projection shows.
Giants vs Rams Trends for MNF
Giants Trends
- John Harbaugh has closed as an underdog of 7 pts or more 17 times as a head coach. He is 12-5 ATS in those games, the 3rd-best mark (min 15 gams) for any head coach in the Super Bowl era.
- Harbaugh is 15-8 ATS coaching on Monday night.
Rams Trends
- Sean McVay is 33-20-3 ATS off a loss in his career (+$1,077), covering 7 of his last 8 games in this spot.
- McVay is 32-18 to the Under in primetime (6 p.m. ET or later) in his career (since 2017).
Giants vs Rams Viewing Info: Channel, Start Time, Streaming
| Location: | SoFi Stadium |
| Date: | Monday, Sept. 21 |
| Time: | 8:15 p.m. ET |
| TV / Streaming Options: | ESPN | ABC |
Giants vs Rams Inactives
Giants Inactives
CB Deonte Banks (calf)
LB Micah McFadden (neck)
TE Thomas Fidone II
OL J.C. Davis
DL Bobby Jamison-Travis
DL Darius Alexander
S Jason Pinnock
via Dan Salomone on X
Rams Inactives
S Kamren Kinchens (hamstring)
WR Jordan Whittington (quad)
WR Puka Nacua (hip)
WR CJ Daniels
QB Ty Simpson (emergency QB)
OL Bill Murray
Via Sarah Barshop on X
