The San Francisco 49ers and Seattle Seahawks meet in an NFL Week 1 NFC West divisional game. 49ers vs Seahawks kickoff is set for 4:05 p.m. ET from Lumen Field in Seattle, Wash. The game will be broadcast on FOX.
The 49ers are 2.5-point favorites over the Seahawks on the spread (49ers -2.5), with the over/under set at 43. San Francisco is a -118 favorite to win outright; Seattle is -102 to pull off the upset.
Let's get into my 49ers vs Seahawks predictions and NFL picks for Sunday, September 7.
49ers vs Seahawks Prediction
- 49ers vs Seahawks pick: Kenneth Walker Over 59.5 Rushing Yards (-120)
My Seahawks vs. 49ers best bet is on Kenneth Walker to go over his rushing yards prop. Make sure to find the best odds by checking our live NFL odds page.
49ers vs Seahawks Odds
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 43 -110o / -110u | -118 |
| Seahawks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 43 -110o / -110u | -102 |
49ers vs Seahawks NFL Week 1 Preview
If you've followed by preseason NFL content, then you know I'm very in on the 49ers this season — that said, this is a bad spot for them.
The 49ers enter the season with a bunch of injuries (notably, Christian McCaffrey popped up on the injury report), and Seattle is a tough draw for Robert Saleh's first game back as defensive coordinator.
Seahawks head coach Mike MacDonald's defensive schemes have been great against Kyle Shanahan and Sean McVay-type offenses, and he had an entire offseason to prepare for this game against the 49ers.
There's also one key matchup that's very worrying for San Francisco: Seattle's run game.
Klint Kubiak is the new playcaller in Seattle, and if the preseason was any indication, his presence could transform this Seahawks' rushing attack, led by Kenneth Walker III and Zach Charbonnet.
A young offensive line that was widely panned as a consensus bottom-three in the league suddenly looked outstanding. The Seahawks were ripping off big runs left and right.
San Francisco's pass defense was good last season, but it ranked in the bottom 10 in DVOA against the run.
The 49ers allowed the fifth-most fantasy points to opposing running backs last season, letting 10 RBs rush for 70+ yards and giving up a league-high 18 rushing touchdowns to opposing RBs.
49ers vs Seahawks Prediction, Betting Analysis
Kenneth Walker III looks healthy and should get plenty of touches in Klint Kubiak's system. He had a touchdown in both 49ers games last fall.
I likeWalker to go over 59.5 yards, and as a slight escalator, I'm taking the rushing yards over with an anytime touchdown for a parlay.
49ers vs Seahawks Best Bets
- Kenneth Walker Over 59.5 Rushing Yards (-120)
- Kenneth Walker Over 59.5 Rushing Yards + Anytime TD (+323, FanDuel)
Spread
I'm not betting either side of the spread in this contest.
Moneyline
I will also be staying away from the moneyline market.
Over/Under
I have no bet on the game total. My Seahawks vs. 49ers betting prediction is Kenneth Walker to record 60+ rushing yards.
