NFL Week 4 opens with a West Coast blockbuster with the Seattle Seahawks and Arizona Cardinals.
For Seahawks-Cardinals, we've compiled eight Thursday Football predictions that feature best bets from our top NFL experts.
Among our expert TNF picks are seven Seahawks vs Cardinals prop bets and TD picks — featuring big names like Jaxon Smith-Njigba, Trey McBride, Kyler Murray and Sam Darnold — and a pick for the spread.
Thursday Night Football Predictions (Seahawks vs Cardinals)
- Seahawks -1.5 (-105; bet365) | Seahawks -6.5 alt line (+200; bet365)
- Tory Horton Over 22.5 Receiving Yards (-115; DraftKings)
- Jaxon Smith-Njigba Over 6.5 Receptions (-118; DraftKings)
- Trey McBride Over 60.5 Receiving Yards (-110; BetMGM)
- Sam Darnold Over 20.5 Pass Completions (+115; Fanatics)
- Kyler Murray Over 27.5 Rushing Yards (-110; DraftKings)
- Trey McBride Anytime Touchdown (+190; bet365)
- Jaxon Smith-Njigba Anytime Touchdown (+176; FanDuel)
Seahawks vs Cardinals Best Bet
Seahawks -1.5
The Cardinals were 2.5-point favorites on Sunday morning but the line has since swung Seattle's direction, with the Seahawks now a slight favorite.
Typically that might be reason to fade the line move, but in this case, it's telling a story about the injuries, which are always key in a short-week game.
Seattle gets S Julian Love and star CB Devon Witherspoon back healthy, restoring its talented secondary, while Arizona is dealing with cluster injuries in both the secondary and offensive line.
Star rookie CB Will Johnson is doubtful and three starters on the line are questionable, with Paris Johnson Jr. an especially big miss if out.
I would've liked Seattle already in this spot, but we haven't lost value by waiting — we gained valuable information on those injuries.
A banged-up Cardinals secondary could have a hard time stopping a Seahawks passing attack that's been better than you think. Sam Darnold is PFF's No. 1 graded QB through three weeks!
Seattle actually leads the NFL in DVOA through three weeks, top six on both offense and defense and lapping the field in special teams. Arizona has played the terrible Saints and Panthers — plus the 49ers' backups — and not really looked impressive at any point.
These teams are being rated as relative peers, but Seattle has been much better thus far. The Seahawks are also benefiting from new OC Klint Kubiak revitalizing the offense, while the Cardinals' run game has gone completely missing due to linemen injuries and the loss of run coordinator Klayton Adams to Dallas. Don't forget James Conner is out now as well.
Seattle has won seven straight against the Cards, with only one of those games within seven points.
Give me Seattle -1 (BetRivers), and you can place part of your bet on Seahawks -6.5 at +200 (bet365) for a slight escalator if you think Seattle's dominance in this rivalry continues.
Seahawks vs Cardinals Player Props
Tory Horton Over 22.5 Receiving Yards (-115; DraftKings)
By Chris Prince
This number continues to climb for Tory Horton this week(already up to 25.5 on a few books), so I'm locking this in early at 22.5 before it goes away. Horton's role continues to grow by the week, as he saw a season high in both target share (22%) and routes (76%) in week three. He has averaged 4.5 targets per game over the past two weeks, producing 32 receiving yards in each of those games.
Arizona is dealing with some injuries to their secondary, and with Jaxon Smith-Njigba playing at such a high level, Horton should find himself in some advantageous matchups for this Seattle offense to exploit. The Cardinals ranked in the bottom half of the league in receiving yards allowed to wide receivers in 2024, and through three weeks of 2025 they've allowed the sixth most receiving yards to wideouts.
I'd play this up to 27.5 if you miss the boat on the 22.5.
Jaxon Smith-Njigba Over 6.5 Receptions (-118; DraftKings)
By Kyle Murray
This is a big number, but Jaxon Smith-Njigba has proven that he is deserving off a line like this.
The Seahawks shipping out several WRs from last year was the first sign of all the faith they had in this young WR, and now we are seeing them rely on him heavily — he has a 32% target share or higher in all three games this season.
JSN has at least eight receptions in 2-of-3 games this season, with the "down" game coming last week in a 30+ point blowout win against the Saints where he had five catches.
JSN is averaging 7.3 grabs per game on the year while averaging 9.7 targets per game. However, I think he could be in line for some significant volume as this game is projected to be close with a 1.5-point spread against a division rival.
Trey McBride Over 60.5 Receiving Yards (-110; BetMGM)
By Brit Devine
Trey McBride's yardage was held in check against Fred Warner and the 49ers, but I'm looking for the tight end to bounce back in a big way Thursday night.
Seattle has allowed the most receptions to TEs this season, the seventh-most yards, and three TDs already this year. McBride had two big games last year against them, with a ridiculous 29 targets in those games combined.
McBride was also the main zone coverage target last season for the Cardinals; he drew 28% of the targets last season against zone, and while that has dropped off some this year, he still leads the team.
This is important as Seattle has run the eighth-lowest percentage of man coverage snaps this year.
With his receptions prop at 6.5, the yards look like a better target to me. I would play McBride's line to 63.5.
Sam Darnold Over 20.5 Completions (+115; Fanatics)
By Derek Carty
There may be some value on the completions prop for Sam Darnold.
THE BLITZ is projecting him to record 23.85 completions, and the oddsmakers are implying 20.60.
The model believes there is a 66% chance he records at least 20.5 completions, so there is value on the over at +115.
Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics!
Kyler Murray Over 27.5 Rushing Yards (-110; DraftKings)
By Brit Devine
Kyler Murray has gone over this number in every game this year; he has at least six rushing attempts in every game.
Last season when Murray rushed at least six times in a game, he went over this number in 4-of-5 games, and in games he had five rushing attempts, he was over in 3-of-5.
There have been multiple quotes from the team suggesting Murray is looking to run and scramble more this season, which seems to be coming to fruition.
I would play this to 29.5.
TNF Anytime Touchdown Picks
Trey McBride Anytime Touchdown (+190; bet365)
The Seahawks defense has been great this season, but they've struggled against tight ends.
The Seahawks have allowed the most targets and touchdowns to opposing TEs, and have allowed the sixth-most receiving yards.
While Trey McBride hasn't been a huge TD guy in his career despite being the focal point of this passing game since the beginning of last season, the Cardinals have been targeting him in the red zone this season — he is tied for the lead in red-zone targets with Marvin Harrison Jr.
McBride had 21 targets in the red zone last season and he also accounted for 50% of Kyler Murray's targets inside the 5-yard line last season.
McBride should regress to the mean this season and I won't be surprised to see him finish with 8-10 TDs this year.
I have the true odds on McBride around +140 tonight, making this a great EV bet.
Jaxon Smith-Njigba Anytime Touchdown (+176; FanDuel)
By Grant Neiffer
The Seahawks have become one of the most run-heavy teams in the league, but that isn't stopping them from getting the ball to Jaxon Smith-Njigba.
JSN has over a 40% target share on the season, which leads the league.
The matchup against Arizona is just an average one for JSN, but I really don't care considering his workload.
I have the true odds on JSN around +125 tonight, making this a great EV bet.
