Turn your sports knowledge into winning predictions
21+ or 18+ in Certain Locations. 19+ in ON. Please Play Responsibly. Gambling Problem? Call 1-800-GAMBLER. Visit connexontario.ca or Call 1-866-531-2600 in ON.
No Code Needed

Cubs vs. Pirates Odds & Betting Predictions - September 17, 2025

Cubs at Pirates

4:35 pm • MLB Network
Stream Live on SiriusXM - Free 3 Month Offer

Chicago Cubs

87-64
@

Pittsburgh Pirates

65-87
Starting Pitchers
pitcherteameraw-l
Johan Oviedo logoJ.OviedoPittsburgh Pirates logo2.812-0
Matthew Boyd logoM.BoydChicago Cubs logo3.0513-8

Cubs at Pirates Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cubs
87-64
-1.5
-1.5+121
o8-102
-141
Pirates
65-87
u8
+1.5-145
u8-119
+119
location pinWednesday 4:35 p.m.
September 17, 2025
PNC ParkPittsburgh
thermometer image77°Fahrenheit
rain image0%Rain
wind image4Wind
Cubs vs. Pirates Expert Picks
Sean Zerillo
Sean Zerillo
Last 30d: 172-183-5 (-2.0u)
PIT +140
0.5u
Bet to +130
Moneyline Hacks
Moneyline Hacks
Last 30d: 102-122-5 (+40.4u)
CHC -154
2u
🚨Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/A8v49URQaG 🎙️Fade the Noise PODCAST - Subscribe!✅ https://www.youtube.com/@FadetheNoise 🔥70% OFF VIP!! ⬇️⬇️ (COPY & PASTE LINK): https://dubclub.win/r/p/pri-jnydr/?checkout=1&coupon=BookieHacks70

Cubs vs. Pirates Previews & Analysis

  • An Early Plus-Money Edge for MLB Wednesday article feature image

    An Early Plus-Money Edge for MLB Wednesday

    PJ Walsh•
    Sep 17, 2025 UTC
  • Cubs vs Pirates: A Matinee Prediction article feature image

    Cubs vs Pirates: A Matinee Prediction

    Sean Paul•
    Sep 17, 2025 UTC
See more MLB Coverage Right Arrow

Prop Odds Comparison

Right Arrow
Right Arrow

No props found

Line Movement Tracker

Right Arrow
Right Arrow

Cubs vs. Pirates Public Betting Percentages

Away Logo

Cubs

Public

Home Logo

Pirates

81%

Bets%

19%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Pirates are 1-4 in their last 5 games.
  • Pirates are 1-4 in their last 5 games against the spread
  • Pirates are 37-38 in their road games against the spread
  • The totals have gone OVER in 1 of Pirates' last 5 games
  • The totals have gone OVER in 31 of Pirates' 77 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Pirates		82-7045-3237-3818-2662-43
Cubs		71-8035-4036-4050-5820-22

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Pirates		58-86-831-41-527-45-316-26-240-59-6
Cubs		67-75-935-35-532-40-446-55-721-19-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Pirates		65-8742-3523-5221-2343-62
Cubs		87-6446-2941-3568-4018-24

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 16thCHCL 1-4-1.5 LU 6.5CHC -131
Sep 15thCHCL 0-4+1.5 LU 8CHC +102
Sep 14th@WSHL 3-4-1.5 LU 8.5WSH -120
Sep 13th@WSHW 5-1-1.5 WU 9PIT -115
Sep 12th@WSHL 5-6-1.5 LO 8.5WSH -110

Pirates vs. Cubs Injury Updates

Pirates Injuries

  • Johan Oviedo
    SP

    Oviedo is questionable with elbow

    Questionable

  • Endy Rodriguez
    1B

    Rodriguez is out with elbow

    Out

  • Jared Jones
    SP

    Jones is out with elbow

    Out

Cubs Injuries

  • Michael Soroka
    SP

    Soroka is out with shoulder

    Out

  • Justin Steele
    SP

    Steele is out for season with elbow

    Out for Season

See more MLB Injuries Right Arrow
Cubs vs. Pirates Starting Lineups
Cubs Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Matthew Boyd logoLM.Boyd, P13-83.051.0747.67
HITTERSAVGOBPSLGHR
Michael Busch logo1M.Busch, 1B.259.337.49829
Nico Hoerner logo2N.Hoerner, 2B.301.351.4016
Ian Happ logo3I.Happ, LF.241.345.41922
Moises Ballesteros logo4M.Ballesteros, DH.306.390.4721
Dansby Swanson logo5D.Swanson, SS.250.304.42222
Pete Crow-Armstrong logo6P.Crow-Armstrong, CF.248.290.48529
Willi Castro logo7W.Castro, RF.245.335.40710
Matt Shaw logo8M.Shaw, 3B.224.291.37811
Reese McGuire logo9R.McGuire, C.217.238.4258
Pirates Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Johan Oviedo logoRJ.Oviedo, P2-02.811.16910.17
HITTERSAVGOBPSLGHR
Jared Triolo logo1J.Triolo, SS.224.318.3536
Tommy Pham logo2T.Pham, LF.249.330.3749
Bryan Reynolds logo3B.Reynolds, RF.241.311.39615
Nick Gonzales logo4N.Gonzales, 2B.272.311.3775
Andrew McCutchen logo5A.McCutchen, DH.239.334.37613
Alexander Canario logo6A.Canario, CF.219.279.3436
Nick Yorke logo7N.Yorke, 1B.167.189.2220
Joey Bart logo8J.Bart, C.240.349.3112
Cam Devanney logo9C.Devanney, 3B.094.121.1250

Cubs vs. Pirates Odds Comparison

Right Arrow

Could not load odds

See more MLB Odds Right Arrow

Cubs at Pirates Team Totals

MatchupOverUnder
Cubs
87-64
N/A
N/A
Pirates
65-87
N/A
N/A