Astros vs. Guardians Odds & Betting Predictions - April 22, 2026

Astros at Guardians

5:10 pm • SCHN

Houston Astros

@

Cleveland Guardians

pitcher		team	era	w-l
T.Bibee			4.81	0-2
P.Lambert			7.20	0-1

MatchupOpenSpreadTotalMoneyline
Astros 9-16	+1.5	+1.5-170	o8-107	+128
Guardians 14-11	u8	-1.5+140	u8-115	-154

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Wednesday 5:10 p.m.

April 22, 2026

Progressive FieldCleveland

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66°Fahrenheit

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0%Rain

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6Wind

Y.Alvarez o0.5 HR+370

0.25u

P.Lambert u2.5 BB-193

1.93u

HOU +120

1u

Under 4.5 (F5)-130

1.3u

P.Lambert o3.5 Ks-168

1.68u

CLE -135

0.68u

Moneyline Pick for Astros-Guardians
Doug Ziefel•
Apr 22, 2026 UTC

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MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 3-2 in their last 5 games against the spread
Guardians are 6-7 in their road games against the spread
The totals have gone OVER in 4 of Guardians' last 5 games
The totals have gone OVER in 6 of Guardians' 12 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	15-10	9-3	6-7	7-4	8-6
Astros	9-16	6-7	3-9	4-11	5-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	13-12	6-6	7-6	6-5	7-7
Astros	17-7-1	9-4	8-3-1	9-6	7-1-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	14-11	8-4	6-7	7-4	7-7
Astros	9-16	7-6	2-10	5-10	4-5

date	opponent	score	spread	over/under	moneyline
Apr 21st	HOU	W 8-5	-1.5 W	O 8.5	CLE -101
Apr 20th	HOU	L 2-9	-1.5 L	O 7.5	HOU -135
Apr 19th	BAL	W 8-4	+1.5 W	O 6.5	CLE -120
Apr 18th	BAL	W 4-2	-1.5 W	U 7.5	CLE -146
Apr 17th	BAL	L 4-6	-1.5 L	O 8	BAL -141

Zach Dezenzo
LF
Dezenzo is out with elbow
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PITCHER		W-L	ERA	WHIP	K/9
RP.Lambert, P		0-1	7.20	1.600	14.40

HITTERS	AVG	OBP	SLG	HR
1C.Correa, SS	.286	.371	.381	1
2Y.Alvarez, DH	.330	.456	.747	10
3J.Altuve, 2B	.266	.367	.426	3
4C.Walker, 1B	.261	.353	.511	5
5I.Paredes, 3B	.225	.337	.366	2
6C.Smith, RF	.250	.337	.417	3
7D.Johnson, CF	.000	1.000	.000	0
8C.Vazquez, C	.375	.444	.688	2
9B.Matthews, LF	.176	.263	.353	1

PITCHER		W-L	ERA	WHIP	K/9
RT.Bibee, P		0-2	4.81	1.520	8.51

HITTERS	AVG	OBP	SLG	HR
1S.Kwan, CF	.223	.308	.287	1
2C.DeLauter, RF	.221	.322	.506	5
3J.Ramirez, DH	.233	.367	.489	6
4K.Manzardo, 1B	.200	.282	.257	1
5G.Valera, LF	.273	.304	.364	0
6D.Schneemann, 3B	.309	.387	.527	2
7J.Brito, 2B	.171	.244	.244	0
8B.Naylor, C	.137	.200	.216	1
9B.Rocchio, SS	.284	.384	.446	3

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MatchupOverUnder
Astros 9-16	N/A	N/A
Guardians 14-11	N/A	N/A