Pirates vs. Cardinals Odds & Betting Predictions - May 21, 2026

Pirates at Cardinals

5:15 pm • CARD

Pittsburgh Pirates

@

St. Louis Cardinals

pitcher		team	era	w-l
D.May			0.00	0-0
B.Ashcraft			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Pirates 24-24	N/A	N/A	N/A
Cardinals 28-19	N/A	N/A	N/A

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Thursday 5:15 p.m.

May 21, 2026

Busch StadiumSt. Louis

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65°Fahrenheit

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0%Rain

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8Wind

No props found

MLB Public Betting

Cardinals are 4-1 in their last 5 games.
Cardinals are 3-2 in their last 5 games against the spread
Cardinals are 15-8 in their road games against the spread
The totals have gone OVER in 2 of Cardinals' last 5 games
The totals have gone OVER in 12 of Cardinals' 24 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	30-17	15-9	15-8	3-2	27-15
Pirates	25-23	13-13	12-10	15-12	9-11

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	21-23-3	12-11-1	9-12-2	2-3	19-20-3
Pirates	26-21-1	16-10	10-11-1	16-11	9-10-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	28-19	13-11	15-8	3-2	25-17
Pirates	24-24	13-13	11-11	16-11	7-13

date	opponent	score	spread	over/under	moneyline
May 19th	PIT	W 9-6	+1.5 W	O 8	STL -113
May 17th	KC	L 0-2	+1.5 L	U 9.5	KC -120
May 16th	KC	W 4-2	-1.5 W	U 9	STL -112
May 16th	KC	W 5-4	+1.5 W	O 8.5	STL -108
May 14th	@ATH	W 5-4	-1.5 L	U 9.5	STL +101

Jared Jones
SP
Jones is out with elbow
Out

Lars Nootbaar
LF
Nootbaar is out with heel
Out

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MatchupOverUnder
Pirates 24-24	N/A	N/A
Cardinals 28-19	N/A	N/A