The Chicago Cubs host the Cincinnati Reds on May 6, 2026. First pitch from Wrigley Field is scheduled for 7:40 p.m. ET. The game will be broadcast on MARQ.
The Cubs are favored by -181 on the moneyline and by -1.5 on the run line. The Reds are +149 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find our MLB picks and Reds vs Cubs prediction below, as well as probable pitchers, weather report, and more.
Reds vs Cubs Prediction
- Reds vs Cubs Pick: TJ Friedl Over 0.5 Hits (-157)
Our Reds vs Cubs best bet is on TJ Friedl to get one or more hits in this game. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Cubs Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -149 | 8 -112o / -108u | +149 |
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +123 | 8 -112o / -108u | -181 |
- Reds vs Cubs moneyline: Reds +149, Cubs -181
- Reds vs Cubs over/under: 8 (-112o / -108u)
- Reds vs Cubs spread: Reds +1.5 (-149), Cubs -1.5 (+123)
Reds vs Cubs Probable Pitchers
| RHP Brady Singer (CIN) | Stat | RHP Colin Rea (CHC) |
|---|---|---|
| 2-2 | W-L | 4-1 |
| 0.0 | fWAR (FanGraphs) | 0.5 |
| 5.57 / 6.17 | ERA / xERA | 4.41 / 4.41 |
| 5.74 / 4.78 | FIP / xFIP | 3.42 / 3.62 |
| 7.2 | K-BB% | 14.8 |
| 41.0 | GB% | 52.5 |
| .348 | BABIP | .313 |
| 93 | Stuff+ | 94 |
| 98 | Location+ | 102 |
Reds vs Cubs MLB Betting Preview
Action PRO projects Reds CF TJ Friedl for 1.2 hits in tonight's matchup against the Cubs, giving us a solid 9.8% edge against the market when compared to his current prop line of over/under 0.5, which is good enough to mark the over with a B- grade in our system.
After an awful start to the season, with averages of .100 and .207 in March and April, respectively, he's been heating up with a .256 AVG in the past two weeks.
Tonight, he will face Colin Rea, who's getting pummeled by left-handed batters this season, with a .305 average compared to the meager .188 that right-handed batters are getting against him.
Reds vs Cubs Pick, Betting Analysis
Friedl has surpassed this 0.5 line in seven of his last 10 games.
After two hitless games in this series, chances are he will come up with at least one today.
With a great matchup, let's back him to get 1+ hits against Chicago.
Pick: TJ Friedl Over 0.5 Hits (-157, DraftKings)
