The Chicago White Sox host the Cleveland Guardians on June 23, 2026. First pitch from Rate Field is scheduled for 7:40 p.m. EDT. The game will be broadcast on CLEG.
The Guardians are favored by -112 on the moneyline and by -1.5 on the run line. The White Sox are -104 on the moneyline and +1.5 on the run line. The total is set at 7 runs.
Find my MLB picks and Guardians vs White Sox prediction below, as well as probable pitchers, weather report, and more.
Guardians vs White Sox Prediction
- Guardians vs White Sox Pick: Under 7
My Guardians vs White Sox best bet is on the Under Make sure to find the best odds by checking our live MLB odds page.
Guardians vs White Sox Odds
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +162 | 7 -118o / -104u | -112 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -196 | 7 -118o / -104u | -104 |
- Guardians vs White Sox moneyline: Guardians -112, White Sox -104
- Guardians vs White Sox over/under: 7 (-118 / -104)
- Guardians vs White Sox spread: Guardians -1.5 (+162), White Sox +1.5 (-196)
Guardians vs White Sox Probable Pitchers
| Parker Messick (LHP, CLE) | Stat | Sean Burke (RHP, CWS) |
|---|---|---|
| 7-3 | W-L | 4-4 |
| 2.2 | fWAR (FanGraphs) | 1.2 |
| 2.70 / 3.33 | ERA / xERA | 3.89 / 3.98 |
| 3.20 / 3.43 | FIP / xFIP | 3.96 / 4.18 |
| 18.3% | K-BB% | 15.4% |
| 42.3% | GB% | 35.0% |
| .272 | BABIP | .282 |
| 96 | Stuff+ | 98 |
| 106 | Location+ | 103 |
Guardians vs White Sox MLB Betting Preview
This game triggered one of our Action PRO betting systems, powered by Evan Abrams:
In matchups between winning teams, sportsbooks often inflate totals based on perceived offensive strength, yet these teams also tend to have stronger pitching and tighter late-game execution, creating a profitable edge on the Under.
Guardians vs White Sox Pick, Betting Analysis
I really like this starting pitching matchup.
Parker Messick is carving opponents up with his fastball-changeup combination, while Sean Buke is one of the only good pitchers in the White Sox rotation.
Of greater importance, these two lineups are super watered down without their best players, as Munetaka Murakami and Jose Ramirez remain on the shelf.
While I'm scared of backing the White Sox bullpen, which is both bad and fatigued, the Guardians have a top-10 relief staff, which should help us stave off too many late-game runs.
Pick: Under 7
