The Chicago White Sox host the Cleveland Guardians on June 22, 2026. First pitch from Rate Field is scheduled for 7:40 p.m. EDT. The game will be broadcast on CHSN.
The Guardians are favored by -112 on the moneyline and by -1.5 on the run line. The White Sox are -108 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Guardians vs White Sox prediction below, as well as probable pitchers, weather report, and more.
Guardians vs White Sox Prediction
- Guardians vs White Sox Pick: Gavin Williams Over 5.5 Strikeouts
My Guardians vs White Sox best bet is a prop ladder on Cleveland starting pitcher Gavin Williams. Make sure to find the best odds by checking our live MLB odds page.
Guardians vs White Sox Odds
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +148 | 7.5 -118o / -102u | -112 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -180 | 7.5 -118o / -102u | -108 |
- Guardians vs White Sox moneyline: Guardians -112, White Sox -108
- Guardians vs White Sox over/under: 7.5 (-118o / -102u)
- Guardians vs White Sox spread: Guardians -1.5 (+148), White Sox +1.5 (-180)
Guardians vs White Sox Probable Pitchers
| RHP Gavin Williams (CLE) | Stat | LHP Anthony Kay (CWS) |
|---|---|---|
| 9-4 | W-L | 6-2 |
| 1.3 | fWAR (FanGraphs) | 0.2 |
| 3.83 / 4.74 | ERA / xERA | 4.61 / 5.65 |
| 4.03 / 3.29 | FIP / xFIP | 5.32 / 4.93 |
| 19.8% | K-BB% | 8.4% |
| 46.6% | GB% | 44.1% |
| .269 | BABIP | .288 |
| 104 | Stuff+ | 104 |
| 101 | Location+ | 101 |
Guardians vs White Sox MLB Betting Preview
The BUY signal is lit up on Gavin Williams. He's gone through a rough patch with a 4.84 ERA over his last eight starts, and he's coming off a really rough outing in which he gave up seven earned runs to the Brewers. Now comes the good news. Over that span:
- 25.3% K%
- 5.6% BB%
- 15.3% SwStr%
- 32.4% Ball%
He is throwing strikes, and he is still getting a bunch of whiffs — but he just hasn't been able to put guys away (40% Strike% in two-strike counts, which is an astounding 10 points below his overall average during this stretch), and also, he hasn't had any good fortune when the ball has been put into play (12.1% Brl% allowed, resulting in six home runs).
The White Sox are lacking raw power with Murakami on the shelf. Colson Montgomery is doing his part, but the rest of the lineup is pretty weak relative to the current environment in Major League Baseball. So I like Williams' chances in this one. If he just keeps doing what he's been doing, with normal "luck" measures, he'll be a pretty awesome pitcher for the Guardians.
But he probably won't get much run support. With Jose Ramirez out right now, this Guardians lineup looks rough. Cleveland owns an OPS near the bottom of the league in June, barely above .650. Only three teams are worse this month. And it's even worse against lefties. If we go back to the middle of May, when they still had J-Ram, they're hitting .217/.308/.327 against left-handed pitching with seven home runs. That's tied for the third fewest in baseball over that span, and Cleveland has seen the third-most plate appearances against lefties during that time.
So that's all good news for Anthony Kay. He's no All-Star, but he's proven capable of hanging in the big leagues with a 3.78 SIERA over his last seven starts.
PROJECTIONS
- Williams: 6.1 IP, 4.9 H, 2.6 ER, 6.8 K, 2.3 BB
- Kay: 4.2 IP, 4.9 H, 2.6 ER, 4.6 K, 2.3 BB
SIM RESULTS:
- Guardians win 51% of games
- Average total of 8.55 runs
Nothing really stands out here. The sim is mostly in line with the over/under of eight. But I'm looking for opportunities to bet on Gavin Williams. The lines are loosening up after the rough patch he's had, and we should jump on that.
Pick: Gavin Williams Strikeouts Ladder
- Over 5.5 Strikeouts (-153)
- Over 6.5 Strikeouts (+135)
- Over 7.5 Strikeouts (+275)
