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Rockies vs Diamondbacks Prediction, Pick, MLB Odds for Friday, May 22

Rockies vs Diamondbacks Prediction, Pick, MLB Odds for Friday, May 22 article feature image
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May 21, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks catcher Gabriel Moreno (14) scores the game winning run against the Colorado Rockies during the ninth inning at Chase Field. Mandatory Credit: Joe Camporeale-Imagn Images

The Arizona Diamondbacks host the Colorado Rockies on May 22, 2026. First pitch from Chase Field is scheduled for 9:40 p.m. EDT. The game will be broadcast on ARID.

The Diamondbacks are favored by -210 on the moneyline and by -1.5 on the run line. The Rockies are +176 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.

Find my MLB picks and Rockies vs Diamondbacks prediction below, as well as probable pitchers, weather report, and more.


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Rockies vs Diamondbacks Prediction

  • Rockies vs Diamondbacks Pick: Diamondbacks ML (-200 or Better)

My Rockies vs Diamondbacks best bet is on the Snakes. Make sure to find the best odds by checking our live MLB odds page.


Rockies vs Diamondbacks Odds

Rockies Logo
Friday, May 22
9:40 p.m. ET
ARID
Diamondbacks Logo
Rockies Odds
SpreadTotalMoneyline
+1.5
-120
8.5
-122o / -100u
+176
Diamondbacks Odds
SpreadTotalMoneyline
-1.5
+100
8.5
-122o / -100u
-210
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Rockies vs Diamondbacks moneyline: Rockies +176, Diamondbacks -210
  • Rockies vs Diamondbacks over/under: 8.5 (-122 / +100)
  • Rockies vs Diamondbacks spread: Diamondbacks -1.5 (+100), Rockies +1.5 (-120)

Rockies vs Diamondbacks Polymarket Odds


Rockies vs Diamondbacks Probable Pitchers

Tomoyuki Sugano (RHP, COL)StatMichael Soroka (RHP, ARI)
4-3W-L6-2
0.0fWAR (FanGraphs)1.1
4.02 / 7.23ERA / xERA3.49 / 4.77
5.48 / 4.94FIP / xFIP2.96 / 3.19
5.6%K-BB%19.5%
41.9%GB%39.0%
.247BABIP.351
79Stuff+93
104Location+107

Rockies vs Diamondbacks MLB Betting Preview

Editor’s Note: This written pick is a transcription from today’s episode of the Payoff Pitch Podcast.

The Snakes are playing good ball right now. I think they’re starting to trend up, though I wish the starting pitching were a little better. Still, this is a potential Wild Card squad.

At the same time, the Rockies have started to taper off after their hot start. Their bullpen is just so bad, and also more strained than the Diamondbacks bullpen.

Tomoyuki Sugano has been okay, but I still don’t project him as a viable long-term option — I power rate him as SP No. 149 out of 160. I think he’ll struggle against Arizona’s patient lineup.

Additionally, Arizona is due for some breakouts, like Lourdes Gurriel Jr. The Diamondbacks have Gabriel Moreno batting seventh! This is a very deep lineup that takes a lot of pitches and draws plenty of walks.

Throw in the massive starting pitching edge and solid bullpen (I really like Paul Sewald), and I’m all over the Snakes on Friday.

Pick: Diamondbacks ML (-200 or Better)


Rockies vs Diamondbacks Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Sean graduated from the University of Miami and Hofstra University Law School, later passing the New York State Bar Exam in 2014. He shifted from a legal career to sports data and betting, joining the Action Network in 2019 after working as a baseball video scout and in financial regulatory compliance. As a senior writer and betting analyst, Sean provides MLB and MMA projections using proprietary models and contributes to various digital content and podcasts, becoming a leading expert in betting for baseball, MMA, and horse racing.

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