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Astros vs Athletics Prediction, Pick, MLB Odds for Sunday, September 27

Astros vs Athletics Prediction, Pick, MLB Odds for Sunday, September 27 article feature image
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Pictured: Houston Astros shortstop Jeremy Pena celebrates with right fielder Cam Smith. (Credit: Dennis Lee-Imagn Images)

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The Athletics host the Houston Astros on September 27, 2026. First pitch from Sutter Health Park is scheduled for 3:05 p.m. EDT. The game will be broadcast on SCHN.

The Astros are favored by -187 on the moneyline and by -1.5 on the run line. The Athletics are +154 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.

Find our MLB picks and Astros vs Athletics prediction below, as well as probable pitchers, weather report, and more.


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Astros vs Athletics Prediction

  • Astros vs Athletics Pick: Jeremy Pena Over 1.5 Hits (+168)

Our Astros vs Athletics best bet is on Jeremy Pena to record over 1.5 hits. Make sure to find the best odds by checking our live MLB odds page. Be sure to download the Action Network app for more picks and analysis.


Astros vs Athletics Odds

Astros Logo
Sunday, Sep 27
3:05 p.m. ET
SCHN
Athletics Logo
Astros Odds
SpreadTotalMoneyline
-1.5
-116
9.5
-106o / -113u
-187
Athletics Odds
SpreadTotalMoneyline
+1.5
-104
9.5
-106o / -113u
+154
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Astros vs Athletics moneyline: Astros -187, Athletics +154
  • Astros vs Athletics over/under: 9.5 (-106o / -113u)
  • Astros vs Athletics spread: Astros -1.5 (-116), Athletics +1.5 (-104)

Astros vs Athletics Probable Pitchers

Peter Lambert (RHP, HOU)StatSeth Johnson (RHP, ATH)
8-10W-L1-0
2.3fWAR (FanGraphs)0.0
3.87/3.73ERA / xERA6.19/4.69
3.94/4.38FIP / xFIP4.63/4.44
14.3%K-BB%13.3%
36.1%GB%36.3%
.282BABIP.356
92Stuff+109
100Location+94

Astros vs Athletics MLB Betting Preview

Playoff race in the American League has reached its absolute deadline, and high stakes surround the regular-season finale. The three Wild Card spots are officially wrapped up, leaving the Houston Astros and Texas Rangers locked in a fight for the final remaining postseason berth.

History is guaranteed in the AL West, as the division champion will finish at or below .500 for the first time in Major League Baseball history. Both Houston and Texas enter Sunday sitting at 80-81, meaning the best possible record for the division champion will be 81-81.

Houston travels to West Sacramento, California to take on the Athletics at Sutter Health Park with their season on the line. The Astros are aiming to capture their eighth division crown over the past ten campaigns, holding a 41-39 record on the road. Offensively, Houston ranks seventh in the AL with a team batting average of .242.

The hosting Athletics sit at 64-97 overall, including a 32-48 mark on their home field. Despite their record, A's offense features solid pop, ranking 10th in MLB with a .403 team slugging percentage. This marks the 13th meeting between the two clubs this season, with the head-to-head series tied dead even at 6-6.

On the mound, Houston sends right-hander Peter Lambert to the bump. Lambert holds an 8-10 record alongside a 3.87 ERA, 1.26 WHIP, and 153 strikeouts over 153.2 innings. The Athletics counter with righty Seth Johnson, who carries a 1-0 record, a 6.19 ERA, a 1.69 WHIP, and 38 strikeouts in limited action.


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Astros vs Athletics Pick, Betting Analysis

Jeremy Pena enters Sunday on a massive heater. The Astros shortstop put on a show during Saturday's 13-2 blowout victory over Athletics, racking up four hits in a dominant effort.

Over his previous 10 games, Pena has been on fire at the plate, going 16-for-46 with a double, a triple, five home runs, and eight RBIs.

Action PRO projections favor to keep his momentum going projecting him for 1.96 hits in Sunday's matchup.

Compared to his current prop line set at over/under 1.5 hits, this projection creates a strong 21.1% edge against the market. That value gives the over an A grade in the projection system, making the Over 1.5 hits the premier play for this big matchup.

Pick: Jeremy Pena Over 1.5 Hits (+168)


Astros vs Athletics Weather


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