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MLB Home Run Picks Today: Grant Neiffer’s Props for Cardinals vs Phillies, Twins vs Padres, More for Saturday, August 22

MLB Home Run Picks Today: Grant Neiffer’s Props for Cardinals vs Phillies, Twins vs Padres, More for Saturday, August 22 article feature image
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Aug 21, 2026; Philadelphia, Pennsylvania, USA; St. Louis Cardinals right fielder Joshua Baez (22) runs the bases after hitting a two RBI home run during the first inning against the Philadelphia Phillies at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images

Happy Saturday!

I've got four MLB home run picks today, including bangers for Cardinals vs Phillies and Twins vs Padres on August 22.


MLB Home Run Picks Today

GameTime (ET)Pick
St. Louis Cardinals LogoPhiladelphia Phillies Logo
6:05 PM
Tampa Bay Rays LogoBaltimore Orioles Logo
7:05 PM
Detroit Tigers LogoKansas City Royals Logo
7:15 PM
Minnesota Twins LogoSan Diego Padres Logo
8:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.


Grant Neiffer's Cardinals vs Phillies Home Run Pick

St. Louis Cardinals Logo
46256
6:05 PM ET
MLB.TV
Philadelphia Phillies Logo
Joshua Baez Home Run
FanDuel Logo

Last night, Joshua Baez broke his small cold streak since his major league debut, and he gets a great spot tonight.

Andrew Painter has been a bit of a gas can for righty power this season, allowing 1.65 HR/9.

The ballpark is an upgrade even with below-average weather.

I have the true odds on this home run prop around +500.

Pick: Joshua Baez Home Run



Grant Neiffer's Rays vs Orioles Home Run Pick Today

Tampa Bay Rays Logo
46256
7:05 PM��ET
MLB.TV
Baltimore Orioles Logo
Junior Caminero Home Run
FanDuel Logo

Brandon Young has been a gas can for righty power, allowing a 1.7 HR/9 in his career and a 1.54 HR/9 this season.

Caminero is one of the best home run hitters in the league, and I have the true odds on this home run prop around +200.

Pick: Junior Caminero Home Run



Grant Neiffer's Tigers vs Royals Home Run Pick Today

Detroit Tigers Logo
46256
7:15 PM ET
MLB.TV
Kansas City Royals Logo
Bobby Witt Home Run
FanDuel Logo

We haven't seen much of Drew Anderson in the majors since 2021, but he was a plus matchup for righty power, and this season is no different, allowing an above-average 1.5 HR/9.

The ballpark and weather aren't great for home runs today, but the odds more than make up for it.

I make the true odds on this home run prop around +450.

Pick: Bobby Witt Home Run



Grant Neiffer's Twins vs Padres Home Run Pick Today

Minnesota Twins Logo
46256
8:40 PM ET
MLB.TV
San Diego Padres Logo
Jackson Merrill Home Run
FanDuel Logo

Dean Kremer has always been a plus matchup for lefty power, allowing an above-average 1.52 HR/9, but this season, he's been an absolute gas can for power, allowing a massive 1.99 HR/9 to lefties.

The weather is above average for lefty power, and Merrill has been much better since his slow start to the season, hitting 11 bombs since the beginning of July.

I have the true odds on this home run prop around +500.

Pick: Jackson Merrill Home Run



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Grant NeifferVerified Action Expert

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