A trio of divisions have been clinched and a trio are still up for grabs as MLB's regular season approaches its final weekend.
There are 12 games on the slate for today, September 25, and our MLB betting experts and systems have found value on the board.
After looking up the latest MLB odds, they've settled on their favorite MLB predictions, so continue reading for today's MLB best bets.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 12:40 p.m. | |
  | 1:05 p.m. | |
  | 7:05 p.m. | |
  | 9:40 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Allan Lem's Pirates vs Reds Best Bet: Back the Pitchers
By Allan Lem
I don’t love the fact that Nick Lodolo will likely face nine right-handed batters here, but this is a must-win game for the Reds, and I can’t imagine they’ll leave him out there if he’s struggling or in a pickle. This should be an all-hands-on-deck situation for the Reds, so we should get their best pitching against one of the worst offenses in baseball.
On the other side, we’re getting Braxton Ashcraft, who I like long-term. He has a 2.62 ERA backed by a 3.45 xERA. He has an 8.5% walk rate and a 0.41 HR/9 ratio. I don’t think this is a fluke.
Let’s back the pitching.
Pick: Under 8 (-104)
| | | |
Sean Zerillo's Rays vs Orioles Best Bet: Over/Under Pick Showing Value
By Sean Zerillo
Drew Ramussen has been limited to 70-80 pitches in September appearances, so I anticipate another short leash in his final start of the season.
He's struggled in September, posting a 4.96 xFIP, a 5.3% K-BB% and a 4.12 botERA. Comparatively, he had a 3.54 xFIP, a 17% K-BB% and a 3.06 botERA through August.
Meanwhile, Cade Povich (5.06 ERA, 5.65 xERA) can’t avoid hard contact (47.7%; fourth percentile) despite a solid K-BB% (15.8%), and has had home run issues throughout his career (1.40 HR/9).
There are expected to be scattered thunderstorms in the area and humidity over 90%, along with winds blowing out at 7-8 mph to left-center. As a result, I project 9.1 runs for this game and would bet over 8.5 to -115.
Pick: Over 8.5 (-110)
| | | |
Bet Labs' White Sox vs Yankees Best Bet: Over/Under Prediction
By Bet Labs
The "Steam Unders with Low OU Support" betting system is built on the premise that sharp money moving totals downward, paired with weak public support on the under, creates an exploitable edge in the betting market.
The strategy focuses on regular season games from 2019 to 2025 in which the closing total lands between eight and 10 — sweet spots for scoring volatility. It isolates games where the over/under line has dropped significantly from open to close, signaling smart money on the under, yet public sentiment heavily favors the over, with only a small share of bets backing the under. This mismatch between money and ticket count indicates potential value, especially when the difference between those two figures is meaningful, but not extreme.
To reduce noise, the system excludes games played in extreme heat or cold, only including those where temperatures range from mild to warm. It also requires both teams to have a recent record of games that hover around the total, suggesting no extreme streaks skewing expectations. These filters ensure that neither team is riding unsustainable over or under trends.
Ultimately, this system looks for low-confidence unders that have been steamed down by sharp bettors, where public interest is light and the number still sits within a realistic scoring range. The result is a consistent edge, backed by a high sample size and a strong return on investment.
Overall, this system has produced a 14% ROI as it has cashed 59% of its picks (586-402-48). This season, the system has stayed hot — cashing 60% of its picks (168-114-10) and generating a 14% ROI.
Pick: Under 8.5 (-103)
| | | |
Bet Labs' Rockies vs Mariners Best Bet: System Suggests Under
By Bet Labs
The "Wind Whisper Unders" system is built for MLB totals where weather and market signals align quietly, but consistently toward the under. It targets regular season games from 2020 through 2025 where the closing total falls between seven and 10 runs — a middle range that allows for variance, but avoids extremes.
This strategy homes in on games with a specific weather profile: wind blowing from left, in from right, or straight in, with speeds between three and 15 mph. Combined with moderate temperatures between 30 and 70 degrees, these environmental conditions help suppress deep fly balls without overly skewing the market. Line movement also plays a role as the total must have dropped by up to 2.5 runs from open to close, signaling steady downward pressure from sharper bettors. Importantly, the public is not fully behind the under — support remains modest, falling between 1-55%. This indicates market resistance and helps ensure the number isn’t over-adjusted. By aligning downward line moves, cooling weather patterns, and under-the-radar betting splits, the system consistently identifies games where offense is subtly — but significantly — less likely to break out.
Overall, this system has produced a 14% ROI as it's 510-347-47 (60%). This season, it has cashed 57% of its picks (125-96-9) and generated an 8% ROI.
Pick: Under 8 (-110)
| | | |
