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MLB Picks, Predictions Today: Best Bets for Angels vs Guardians, Cardinals vs A’s, More for Tuesday, May 12

MLB Picks, Predictions Today: Best Bets for Angels vs Guardians, Cardinals vs A’s, More for Tuesday, May 12 article feature image
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We have a 6-game slate today on this Dinger Tuesday, starting early with Angels vs. Guardians at 6:10 p.m. ET and closing with Dodgers vs. Giants at 10:10 p.m. ET.

Our experts have analyzed the matchups and found great options for Tuesday.

Below are five expert MLB picks and predictions for today's slate of games.


MLB Best Bets Today

The team logos in the table below represent the matchups our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Los Angeles Angels LogoCleveland Guardians Logo
6:10 PM
Chicago Cubs LogoAtlanta Braves Logo
7:15 PM
Kansas City Royals LogoChicago White Sox Logo
7:40 PM
St. Louis Cardinals LogoOakland Athletics Logo
9:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.


Evan Abram's Angels vs Guardians MLB Betting System Pick

Los Angeles Angels Logo
Tuesday, May 12
6:10 PM ET
MLB.TV
Cleveland Guardians Logo
Guardians ML
FanDuel Logo

By Evan Abrams

This game triggered one of our Action PRO Betting Systems:

MLB Icon
Evan Abrams – Early Season Rhythm System
the opponent's previous game margin is between -12 and -1
the team’s home/away streak is between 4 and 9 games
the closing moneyline is between -146 and -100
the game is a Conference game
the moneyline change from open to close is between -35 and -5
the team's game number is between 1 and 51
$7,218
WON
362-221-0
RECORD
62%
WIN%

In the early part of the season, teams often develop mini streaks — especially those on extended road or home stands.

When a team with this kind of momentum faces an opponent coming off a solid loss (but not a blowout), the rhythm-driven team can be undervalued.

And when the line modestly shifts in their favor, this indicates sharp support.

Teams in streaks are more "in rhythm" than those shifting locations or rebounding from losses, especially when early-season variance hasn’t fully settled into the betting market.

The Angels lost game one of this series on Monday, 7-2.

Meanwhile, the Guardians are 22-21 — including 11-9 at home — and in first place in the AL Central.

Pick: Guardians ML (-150 or Better)

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Matt Trollo's Cubs vs Braves Pick

Chicago Cubs Logo
Tuesday, May 12
7:15 PM ET
MLB.TV
Atlanta Braves Logo
Cubs ML
FanDuel Logo

By Matt Trollo

Statcast deems Truist Park a perfectly neutral run environment (100 PRF) and also neutral to LH power (100 PHRF), while slightly suppressing RH power (93).

While things could change as Holmes makes adjustments, leading to positive regression in his strikeout rate, his walk issues have me favoring Rea just a bit here, especially considering the 11-day layoff could shorten this particular outing for Holmes more than usual.

A guy who was supposedly moving to the bullpen just a few days ago isn’t likely to have a long leash to pitch through too much trouble.

These are two of the best offenses in the league this year, but at full strength, the Cubs are better than Atlanta with Acuna out. There should be several outs in the latter half of the home team lineup.

The Cubs have the defensive edge over every team in the league, including another good defense. They are also a better base-running team, while Atlanta may have the slightly better bullpen.

Considering I give the road team slight edges almost everywhere, I think they should be slight favorites here and would play them down to even money, reducing bet size to half a unit below the current price of +106.

I have F5 and the full game rated about evenly. Either or even splitting it up is fine, but I’m electing the better price, which is the full game.

Pick: Cubs ML (+100 or Better)

Read Trollo's full Cubs-Braves preview here:

Trollo's Cubs-Braves Preview Image


Grant Neiffer's Royals vs White Sox Home Run Pick Today

Kansas City Royals Logo
Tuesday, May 12
7:40 PM ET
MLB.TV
Chicago White Sox Logo
Bobby Witt Jr. Home Run
FanDuel Logo

By Grant Neiffer

Bobby Witt hasn't hit for a ton of power this season, but the power is there, and this spot is great.

Erick Fedde grades out as an above-average matchup for righty power and has been absolutely crushed this season by righties, giving up a massive 3.32 HR/9.

The weather in Chicago should be great for hitting, with wind blowing out to left field at 20 MPH.

I make the fair odds on this home run prop around +325.

Pick: Bobby Witt Jr. Home Run (+350 or Better)

Check out all of Grant's home run props for Dinger Tuesday here:



Sean Zerillo's Cardinals vs Athletics Projection & Pick

St. Louis Cardinals Logo
Tuesday, May 12
9:40 PM ET
MLB.TV
Oakland Athletics Logo
A's ML
FanDuel Logo

By Sean Zerillo

Editor's Note: This written best bet is a transcription from today's episode of the Payoff Pitch Podcast.

I make the A’s closer to -167.

We’ve seen Jeffrey Springs get back to being around a league-average starter this season, with a 3.80 xFIP, 3.4 xERA, and 4.00 SIERA.

The pitch modeling metrics back up his league-average form, with a 103 Pitching+ and a 15% K-BB — both of those marks are above the Major League average.

Additionally, the A’s offense is significantly better than the Cardinals' offense, and I strongly prefer Sacramento’s bullpen.

Pick: A's ML (-155 or Better)

Get all of Zerillo's MLB projections here.



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