The Chicago Cubs host the St. Louis Cardinals on August 15, 2026. First pitch from Wrigley Field is scheduled for 2:20 p.m. EDT. The game will be broadcast on MARQ.
The Cubs are favored by -176 on the moneyline and by -1.5 on the run line. The Cardinals are +156 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Cardinals vs Cubs prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Cubs Prediction
- Cardinals vs Cubs Pick: Ian Happ Over 0.5 RBI (+195)
My Cardinals vs Cubs best bet is on Ian Happ to go over his RBI total. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Cubs Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +115 | 9.5 -100o / -120u | +156 |
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -138 | 9.5 -100o / -120u | -176 |
- Cardinals vs Cubs moneyline: Cardinals +156, Cubs -176
- Cardinals vs Cubs over/under: 9.5 (-100o / -120u)
- Cardinals vs Cubs spread: Cubs -1.5 (+115 ), Cardinals +1.5 (-138)
Cardinals vs Cubs Probable Pitchers
| RHP Michael McGreevy (STL) | Stat | LHP Matthew Boyd (CHC) |
|---|---|---|
| 4-9 | W-L | 8-1 |
| 1.3 | fWAR (FanGraphs) | 1.2 |
| 3.64/5.68 | ERA / xERA | 3.50/4.68 |
| 4.25/4.22 | FIP / xFIP | 3.95/4.13 |
| 10.3% | K-BB% | 13.1% |
| 43.2% | GB% | 41.4% |
| .277 | BABIP | .288 |
| 81 | Stuff+ | 96 |
| 112 | Location+ | 108 |
Cardinals vs Cubs MLB Betting Preview
Chicago comes into Saturday’s matinee riding solid late-season play, having taken four of their last five matchups against St. Louis.
The North Siders hand the ball to veteran left-hander Matthew Boyd (8-1, 3.50 ERA). Boyd has been a steadying force for the rotation, recording eight wins on the year and allowing two earned runs or fewer in each of his last several starts.
The Cardinals counter with right-hander Michael McGreevy (4-9, 3.64 ERA).
While McGreevy’s surface ERA is respectable, he relies heavily on contact (6.1 K/9) and pitching to his defense. Against a Chicago offense that has generated 5.4 runs per game over their last five outings, pitching into deep counts without swing-and-miss stuff could spell trouble for the young St. Louis starter.
Cardinals vs Cubs Pick, Betting Analysis
PRO Projections flags this prop as a clear value play based on matchup dynamics, lineup context, and situational splits.
Switch-hitting Ian Happ performs significantly better as a left-handed hitter against right-handed pitching. McGreevy relies on putting balls in play rather than racking up strikeouts, giving Happ higher-quality contact opportunities with runners on base.
Driving in runs requires RBI setups. In 2026, Chicago’s top of the order—anchored by high-OBP bats like Pete Crow-Armstrong (.378 OBP) and Alex Bregman (.344 OBP)—has consistently created run-scoring situations ahead of Happ.
Happ historically elevates his production against divisional rivals, particularly St. Louis. Over the course of the 2026 season, he has recorded 20 home runs and 51 RBIs, frequently coming through in middle-of-the-order RBI spots.
Pick: Ian Happ Over 0.5 RBI (+195)
