Nationals vs Padres Prediction, Pick, Odds for Wednesday, June 25

Nationals vs Padres Prediction, Pick, Odds for Wednesday, June 25 article feature image
Credit:

Photo by David Frerker-Imagn Images. Pictured: Nick Pivetta

The San Diego Padres host the Washington Nationals on June 25, 2025. First pitch from PETCO Park is scheduled for 4:10 p.m. EDT; the game will be broadcast on MASN2.

Find my Nationals vs Padres prediction and MLB player prop pick below.

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My Nationals vs Padres Prediction

  • Nationals vs Padres picks: Nick Pivetta Over 5.5 Strikeouts (-160)

My Nationals vs Padres best bet is Nick Pivetta Over 5.5 Strikeouts. Make sure to find the best odds by checking our live MLB odds page.


Nationals vs Padres Odds

Nationals Logo
Wednesday, Jun 25
4:10 p.m. ET
MASN2
Padres Logo
Nationals Odds
SpreadTotalMoneyline
+1.5
-200
7.5
-110o / -110u
+125
Padres Odds
SpreadTotalMoneyline
-1.5
+165
7.5
-110o / -110u
-150
Odds via BetMGM. Get up-to-the-minute MLB odds here.
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Nationals vs Padres Projected Starting Pitchers

LHP MacKenzie Gore (WAS)StatRHP Nick Pivetta (SD)
3-7W-L7-2
2.6fWAR (FanGraphs)1.7
3.19/3.41ERA /xERA3.64/4.01
2.94/2.91FIP / xFIP3.51/3.68
1.19WHIP1.08
25.2K-BB%19.8
35.0GB%32.1
99Stuff+96
104Location+112

Nationals vs Padres Prediction, Pick

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San Diego Padres Player Prop

On paper, this Nationals team does not stand out as a great strikeout matchup, but these Padres pitchers have had success racking up strikeouts.

I also like this split matchup for Pivetta. He has had more success striking out and generating whiffs against lefties, as his CSW% is at 30% against lefties, but just 26.7% against righties.

That will be helpful, as there are six lefties in this projected Nationals lineup.

Pick: Nick Pivetta Over 5.5 Strikeouts (-160)


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Nationals vs Padres Betting Trends


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