Clemson Regional Odds
 | Clemson Tigers | -110 |
 | Kentucky Wildcats | +320 |
 | West Virginia Mountaineers | +350 |
 | USC Upstate Spartans | +1000 |
Read Doug Ziefel's full college baseball betting preview for the 2025 NCAA Regionals here.
1. Clemson Tigers: It has been a season of ups and downs for the Tigers. They started off very strong but went ice cold toward the end of April. However, they found it again in Durham, making a run to the ACC Tournament Championship.
The key for the Tigers is on the mound. If Aidan Knaack and Drew Titsworth struggle, they won’t make it out of this region. But they're due for positive regression, so things are looking up for Clemson.
2. West Virginia Mountaineers: The Mountaineers were a pleasant surprise in the Big 12, going 19-9 in conference play on the way to 41 wins overall.
However, they crashed and burned down the stretch, losing the regular-season title after being swept by Kansas on the final weekend of the season.
What’s concerning is that the struggles were universal over their final 10 games. However, I like them to get right on Friday with a fresh slate and Griffin Kirn on the mound.
3. Kentucky Wildcats: The team the Mountaineers will get right against is the Kentucky Wildcats. Kentucky has been a tough team to figure out, as it's below average offensively, and ace Nate Harris is due for sizable regression.
I get that Kentucky had the ninth-toughest schedule, but going 13-17 in the SEC and finishing five games over .500 is not a tournament-worthy resume.
4. USC Upstate Spartans: USC Upstate won its first-ever Big South title to earn this spot, and it's going to be fun to watch. The Spartans can rake, as they finished the season ranked seventh in wRC+, eighth in average and 13th in OPS.
The Spartans are an upstart club, and I’ll be looking at an over against Clemson and possibly a run line if they play Kentucky on Saturday.
Clemson Regional Picks
Pick: Clemson to Win Clemson Regional (+105 · DraftKings) · USC Upstate vs. Clemson Over 12.5 or Better (Friday, May 30)
