Nashville Regional Odds
 | Vanderbilt Commodores | -275 |
 | Louisville Cardinals | +425 |
 | East Tennessee State Buccaneers | +550 |
 | Wright State Raiders | +5000 |
Read Doug Ziefel's full college baseball betting preview for the 2025 NCAA Regionals here.
1. Vanderbilt Commodores: The Commodores enter the field of 64 as the newly anointed No. 1 team in the country. They went 22-11 in SEC play, finishing No. 1 in RPI, No. 2 in strength of schedule and riding high off an SEC Tournament title.
They're not only a strong pick to win their region but have the upside to win it all in Omaha. Vandy has the deepest pitching staff in the country, ranking ninth in team ERA, sixth in WHIP, and first in xFIP and SIERA.
In these tournament formats, pitching depth is the key to success, and the Commodores have proven they can shut down the top lineups in the country.
2. Louisville Cardinals: The Cardinals are a bit of an enigma. They went .500 in ACC play this season but have some very strong nonconference wins such as Vanderbilt, Texas and Arizona.
They showed they have the potential to take down any team in the country, but they're stumbling into the postseason after losing five straight series to end the regular season, followed by a first-round exit in the ACC Tournament.
3. East Tennessee State Buccaneers: ETSU is not a team to sleep on in this Regional, as it comes in rolling off a SoCon Tournament victory to finish off the year with a 41-15 record.
The Buccaneers were one of the most potent offensive teams in the country, ranking fourth in OPS and 18th in wRC+
Look for them to be very live as underdogs in their first matchup against Louisville, as ace Carter Fink gets to face a cold Cardinals lineup.
4. Wright State Raiders: The Wright State Raiders dominated the Horizon League, going 25-5 in conference play. They did so by outslugging their competition, ranking 22nd in OPS and 32nd in wRC+ nationally.
Unfortunately for them, their pitching is a major issue, as they hold a staff ERA of 6.32. That will be catastrophic against Vandy in the opener and could easily make them 0-2 in the Regional.
Nashville Regional Picks
Vanderbilt to Make the College World Series (+120 · DraftKings): The Commodores' pitching depth gives them the ability to pitch off in their opener against Wright State and save JD Thompson for the two tougher lineups in the region.
They should get through their region handily, so they’ll likely face either Southern Miss or Alabama in a Super Regional series. I like the Commodores to advance, so getting them at plus-money to make it to Omaha is great value.
ETSU as an Underdog vs. Louisville: We talked about how these teams are trending in opposite directions, but a projected pitching matchup of Carter Fink vs. Peter Michael makes the Bucs just +115 underdogs.
I think we’ll get a much better price than that.
Pick: Vanderbilt to Make College World Series (+120) · ETSU as an Underdog vs. Louisville
