Louisville vs. Duke Odds & Betting Predictions - January 27, 2026

Louisville at Duke

12:00 am • ESPN

Louisville Cardinals

23-10

52 - 83

Duke Blue Devils

32-2

MatchupOpenSpreadTotalMoneyline
Louisville 23-10	N/A	N/A	N/A
Duke 32-2	N/A	N/A	N/A

Tuesday 12:00 a.m.

January 27, 2026

Cameron Indoor StadiumDurham

LOU +8.5-105

LOU +8.5-112

0.28u

LOU +8.5-110

$1.10

ADD 0.5u (# Play)

LOU +8.5-105

M.Brown o14.5 Pts-125

$1.25

DUKE -8.5-105

0.95u

Fading the popular dog

LOU +8.5-110

$55.00

LOU +340

$0.20

0.2u (# stab)

LOU +8.5-110

0.55u

M.Brown o14.5 Pts-125

0.63u

C.Boozer o9.5 Rebs-125

0.5u

DUKE -7.5-110

DUKE -7.5-105

LOU +7.5-110

$1.10

Action ✍️ (ADD 1u) Mikel SZN!!

LOU +7.5-110

0.3u

LOU +7.5-110

1.1u

I wanted to target game two of Mikel Brown’s return

LOU +225

$1.00

ACTION ✍️

LOU +6.5-110

$110.00

LOU +7-120

$1.20

ACTION ✍️

Louisville vs Duke: Back at Full Strength
Ryan Minion•
Jan 26, 2026 UTC
3MW's 3 NCAAB Best Bets for Monday
Matt Cox•
Jan 26, 2026 UTC
How to Bet 2 Ranked NCAAB Big Monday Matchups
Action Network Staff•
Jan 26, 2026 UTC

See more NCAAB Coverage

No props found

NCAAB Public Betting

Duke are 5-0 in their last 5 games.
Duke are 2-3 in their last 5 games against the spread
Duke are 8-3 in their road games against the spread
The totals have gone OVER in 3 of Duke' last 5 games
The totals have gone OVER in 8 of Duke' 23 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Duke	19-15	11-12	8-3	15-13	1-0
Louisville	15-18	9-9	6-9	11-13	1-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Duke	12-22	8-15	4-7	10-18	0-1
Louisville	12-21	5-13	7-8	9-15	1-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Duke	32-2	N/A	N/A	26-2	1-0
Louisville	23-10	N/A	N/A	17-7	1-3

date	opponent	score	spread	over/under	moneyline
Jan 24th	WAKE	W 90-69	-	-	-
Jan 17th	@STAN	W 80-50	-11.5 W	U 148.5	DUKE -750
Jan 15th	@CAL	W 71-56	-14.5 W	U 149.5	DUKE -1233
Jan 10th	SMU	W 82-75	-15.5 L	O 156.5	DUKE -1465
Jan 7th	@LOU	W 84-73	-1.5 W	U 161.5	DUKE -112

Mikel Brown
G
Brown is questionable with back
Questionable

Ifeanyi Ufochukwu
C
Ufochukwu is out with undisclosed
Out
Caleb Foster
G
Foster is out with foot
Out

Patrick Ngongba
C
Ngongba is probable with undisclosed
Probable

See more NCAAB Injuries

Louisville

Duke

16-54 (30%)

Field Goals

31-61 (51%)

9-13 (69%)

Free Throws

13-18 (72%)

11-34 (32%)

8-23 (35%)

Rebounds

Assists

Turnovers

Steals

Blocks

Fouls

Could not load odds

See more NCAAB Odds

MatchupOverUnder
Louisville 23-10	N/A	N/A
Duke 32-2	N/A	N/A

Louisville vs. Duke Odds & Betting Predictions - January 27, 2026

Louisville at Duke

Louisville Cardinals

Duke Blue Devils

Louisville at Duke Odds

Spread, Total, Moneyline

Louisville vs. Duke Previews & Analysis

Louisville vs Duke: Back at Full Strength

3MW's 3 NCAAB Best Bets for Monday

How to Bet 2 Ranked NCAAB Big Monday Matchups

Prop Odds Comparison

Line Movement Tracker

Louisville vs. Duke Public Betting Percentages

Louisville

Public

Duke

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Louisville vs. Duke Injury Updates

Louisville Injuries

Duke Injuries

Louisville vs. Duke Odds Comparison

Louisville at Duke Team Totals