The Indiana State Sycamores take on the Duke Blue Devils in Durham, NC. Tip-off is set for 7 p.m. ET on ACC Network.
Duke is favored by -37 points on the spread, and the total is set at 160.5 points.
Here’s my Indiana State vs. Duke prediction and college basketball picks for November 14, 2025.
Indiana State vs Duke Prediction
My Pick: Duke -37
My Indiana State vs Duke best bet is on the Blue Devils to cover the spread. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Indiana State vs. Duke Odds
| Indiana State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+37 -110 | 160.5 -110 / -110 | OFF |
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-37 -110 | 160.5 -110 / -110 | OFF |
- Indiana State vs Duke spread: Duke -37
- Indiana State vs Duke over/under: 160.5 points
Indiana State vs Duke College Basketball Betting Preview
Indiana State Basketball
Indiana State is off to a 2-1 start in the second year under Matthew Graves, with wins over Illinois Tech and SIU Edwardsville. The Sycamores' lone loss was a 92-76 defeat against Charlotte.
The Sycamores are lead by 6-foot-7 forward Ian Scott, a grad transfer from Grace College. Scott averages 14 points and 10 rebounds per game. His strength is around the rim, as 20 of his 24 field goal attempts have come near the bucket.
If Indiana State wants any chance to stay competitive against Duke, it'll need its second-leading scorer, senior guard Sterling Young, to be efficient from the field. Young averages 13 points per game on 12 shots per night.
His strength is catch-and-shoot work, where he's hitting 43%, but he's struggled finishing at the cup this season, shooting just 7-for-20 (35%).
Duke Basketball
Duke is coming into this game off an offensive and defensive clinic against Army. The Blue Devils won that game 114-59 with six players scoring in double figures.
Cameron Boozer continues to be a dominant all-around player for Duke. He posted 15 points, nine rebounds, four assists, two blocks and two steals in 27 minutes at West Point, and I expect a similar line against Indiana State.
Cayden Boozer has emerged over Duke's last two games after a quiet season opener against Texas. His pace and vision as Duke's point guard stands out, especially when he pushes in transition and creates assists immediately after the opposing team scores.
Over his last two games, Cayden has 13 assists to four turnovers while averaging 12 points per game.
Caleb Foster remains Duke's starting point guard and is shooting 56% from the field and 57% from 3. However, Cayden has made a more consistent offensive impact, to the point where a lineup change after the Kansas game wouldn't be surprising.
Indiana State vs. Duke Betting Analysis
This is Duke's final tune-up before facing Darryn Peterson and Kansas. As fun as Cam Boozer is playing bully ball, and as smooth as Evans looks coming off flare screens, Duke's identity continues to be its defense.
Opponents are shooting just 31% from the field against the Blue Devils this season, and Indiana State enters this matchup undersized while ranking 194th in offensive efficiency.
Digging deeper, not a single player in Duke's starting five has allowed a field goal percentage above 28%.
With the defense remaining dominant and the offense getting steady production from Cayden and Dame Sarr, this sets up as another spot where Duke should comfortably cover a big number.
My Pick: Duke -37
