The Eastern Michigan Eagles take on the Buffalo Bulls in Buffalo, NY. Kickoff is set for 3:30 p.m. ET on ESPN+.
Buffalo is favored by -10 points on the spread with a moneyline of -370. The total is set at 52.5 points.
Here’s my Eastern Michigan vs. Buffalo predictions and college football picks for Saturday, October 4, 2025.
Eastern Michigan vs Buffalo Prediction
- Eastern Michigan vs. Buffalo Pick: Under 51.5
My Buffalo vs. Eastern Michigan best bet is on the under. Find the best line available on our live NCAAF odds page.
Eastern Michigan vs Buffalo Odds
| Eastern Michigan Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10 -110 | 52.5 -105o / -110u | +290 |
| Buffalo Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10 -110 | 52.5 -105o / -110u | -370 |
- Eastern Michigan vs Buffalo point spread: Buffalo -10
- Eastern Michigan vs Buffalo over/under: 52.5 points
- Eastern Michigan vs Buffalo moneyline: Eastern Michigan +290, Buffalo -370
Eastern Michigan vs Buffalo Pick, Betting Analysis
Buffalo has dropped two straight games to Troy and UConn, while Eastern Michigan is just 1-4 on the season, with its lone win coming against Louisiana.
So, how should we bet this Week 6 MAC showdown between the Bulls, who were picked to finish fourth in the conference in the preseason poll, and the Eagles, who were selected to finish in eighth?
Our very own Evan Abrams has a system — "Home Fave Unders" — that has the total targeted for this affair. The system has a 14% return on investment (ROI) since its inception and a 1% ROI this season.
"Home Fave Unders" is a college football system built around the idea that strong home favorites often play in ways that reduce overall scoring.
In the regular season, when the home team is favored by between 2.5 and 19.5 points, these matchups frequently turn into controlled games where the favorite manages the pace and protects the lead rather than pushing for maximum points.
Weather conditions also support lower scoring as humidity levels between 40 and 100 and wind speeds from eight to 100 miles per hour make passing and kicking less efficient.
When public betting on the total leans heavily toward one side, especially the over, lines can become inflated, yet the actual game script favors a more conservative outcome.
This combination of home team control, weather impact and public bias creates a consistent edge for the under.
Pick: Under 51.5
