Indiana State (2-0) travels to Bloomington to take on Indiana (2-0) on Friday, Sept. 12. This game kicks off at 6:30 p.m. ET and can be seen on the Big Ten Network.
Indiana has moved out to a 48.5-point favorite in the contest with a total set at 60.5. Indiana State, meanwhile, comes in at +15000 on the moneyline to pull off the upset.
Here’s my Indiana State vs. Indiana prediction and college football picks for Friday, September 12.


Indiana State vs Indiana Prediction
- Indiana State vs. Indiana Pick: Indiana State +52.5 or Better (Live Bet)
My Indiana vs. Indiana State best bet is to wait to back the Sycamores live. Find the best line available on our live NCAAF odds page.
Indiana State vs Indiana Odds
Indiana St Odds | ||
---|---|---|
Spread | Total | Moneyline |
+48.5 -110 | 60.5 -110o / -110u | +15000 |
Indiana Odds | ||
---|---|---|
Spread | Total | Moneyline |
-48.5 -110 | 60.5 -110o / -110u |
- Indiana State vs Indiana Spread: Indiana -48.5 (-110), Indiana State +48.5 (-110).
- Indiana State vs Indiana Over/Under: 60.5 Points
- Indiana State vs Indiana Moneyline: Indiana State +15000, Indiana N/A


Indiana State vs Indiana College Football Betting Preview

Indiana State Sycamores Betting Preview: Sycamores Ready to Step Up?
Indiana State enters off a dominant 38-14 victory over Eastern Illinois last week.
Backup quarterback Keegan Patterson came in for injured Elijah Owens to lead the second-half charge against the Panthers and figures to get the call this week on short rest against Indiana.
The offense moved the ball efficiently in the first half, and the defense forced EIU to punt on five of its first-half possessions.
The Sycamores looked impressive against the struggling OVC Panthers, but this week will provide different challenges against a top-25 FBS opponent.
The defense will likely be stressed with attempting to contain the Hoosiers offense, which has averaged 547 yards per game and seven yards per play so far this year.

Indiana Hoosiers Betting Preview: Hoosiers Primed to Roll on Offense
Indiana is coming off a 56-9 home win over Kennesaw State last week, and for the second consecutive week, the Hoosiers started a bit sluggish offensively.
Indiana had two punts early and was stopped on downs in the second quarter, but the offense exploded for five second-half touchdowns to bust open what was a 21-9 game.
IU head coach Curt Cignetti was critical of his defensive secondary in the win, talking about the need to have players in better positions against the pass.
He praised the defensive line and rush unit, which registered two sacks and 14 tackles for loss last week.

Indiana State vs Indiana Pick, Betting Analysis
This is a fascinating matchup between a bottom-level Missouri Valley team in Indiana State and the Big Ten Hoosiers.
I laid the big number earlier in the week when it opened up at -41.5, but this line has exploded too far for me to play now. I think I'll look at this one live for an opportunity to take Indiana State at +56.5 or so.
I expect Indiana to put up a big number here, and Cignetti really wants to see this offense start out strong after two sluggish first-half performances thus far.
I can see the execution being a focus in this one, especially early in the game.
Indiana quarterback Fernando Mendoza should get some work early. The run game has been really solid all season, so I expect explosive run plays and quick scores from Indiana in the first half.
The handicap here is that Indiana State is coached by Curt Mallory.
His father, Bill Mallory, is revered by Indiana as the all-time winningest coach in school history. Indiana is honoring one of Mallory’s Indiana teams of the 1990s, and I can just see the dogs getting called off early here once the game is completely out of reach and the Hoosiers' second team comes in.
Indiana has shown this type of approach in prior games with Indiana State, and while I don’t think Cignetti cares either way, he will show mercy in the second half once the score is out of hand, as not to embarrass the son of an IU coaching legend.
With the spot and Illinois on deck, there could be some motivation to extend the game margin early and get Mendoza to the bench.
I'd look for a spot in the game here to snag Indiana State live at +52.5 or better, and I think we'll get the opportunity.
I still like the play we made at the opener of -41.5 with the Hoosiers, so let's hope they get up in this one early and we can jump in for a nice middle opportunity.
Pick: Indiana State +52.5 or Better (Live Bet)