The Louisiana Ragin' Cajuns take on the Eastern Michigan Eagles in Ypsilanti, Michigan. Kickoff is set for 3:30 p.m. ET on ESPN+.
Louisiana is favored by 2.5 points on the spread with a moneyline of -140. The total is set at 50.5 points.
Here’s my Louisiana vs. Eastern Michigan prediction and college football picks for Saturday, September 20, 2025.
Louisiana vs E. Michigan Prediction
- Louisiana vs. Eastern Michigan Pick: Eastern Michigan +3 or Better
My Eastern Michigan vs. Louisiana best bet is on the Eagles as road 'dogs. Find the best line available on our live NCAAF odds page.
Louisiana vs Eastern Michigan Odds
| Louisiana Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 50.5 -110o / -110u | -140 |
| E. Michigan Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 50.5 -110o / -110u | +120 |
- Louisiana vs Eastern Michigan point spread: Louisiana -2.5
- Louisiana vs Eastern Michigan over/under: 50.5 points
- Louisiana vs Eastern Michigan moneyline: Louisiana -140, Eastern Michigan +120
Louisiana vs Eastern Michigan Pick, Betting Analysis
I'm going back to the well and backing Chris Creighton as an underdog.
Eastern Michigan should have covered every number against Kentucky last week if not for a clear missed offsides, a bizarre late fake punt, poor fourth down variance and a Kentucky field goal that banked in from 50-plus in the second half.
While the Eagles ultimately lost by 25, they amassed 461 total yards of offense on the road against an SEC defense that had held Ole Miss to six fewer the week prior on the same field in Lexington.
Eastern Michigan's offense actually has some real juice with quarterback Noah Kim.
The same can't be said for its defense, which I expect to struggle immensely this season. The Eagles rank near the bottom of FBS in almost every possible category, but I'm not sure Louisiana can take full advantage.
The Ragin' Cajuns lost their original starting quarterback, Walker Howard, to an injury, which opened the door for Daniel Beale, who struggled as a true freshman in 2024 despite limited action. He finished last season 13-for-30 passing for 126 yards with no touchdowns and two interceptions.
This year hasn't gone much better.
Beale relieved Howard in the opener against Rice and went 0-for-6 passing in a home loss to Rice in which ULL only scored 12 points. In the following week against McNeese State, Beale only threw for 86 yards on 22 attempts against an FCS school that gave up 42 to Weber State last week. While Louisiana won that game 34-10, that final is a bit misleading, as it was 20-10 late in the fourth quarter before two short field touchdowns, including a fumble return.
So, did the offense make any progress last week against Missouri? Absolutely not.
Louisiana decided to use two quarterbacks in Columbia with Beale and sophomore Lunch Winfield, who is more of a dual-threat. That pair combined to complete 2 of 14 passes for four yards. That's not a typo.
Louisiana somehow scored 10 points thanks to a tipped pick and one broken long run. If you remove that run, they had 37 total yards on the other 36 plays. In the second half alone, they ran nine plays for -2 yards.
The offense is completely broken.
Give me the more desperate home team searching for its first win on its home field, where it was last embarrassed by Long Island. I like what I saw last week from the offense again, and the defense showed some real fight following a few schematic and lineup changes.
Louisiana will have success on the ground with Bill Davis and company. Still, Eastern Michigan has the more reliable offense and better quarterback in addition to the superior coach, who should find a way to pull out a close one by winning in the margins in typical EMU fashion with solid special teams and mistake-free football.
Pick: Eastern Michigan +3 or Better
