Michigan vs Oklahoma Prediction, Pick, Odds for Saturday, September 6 article feature image
3 min read
HomeRight ArrowNCAAF

Michigan vs Oklahoma Prediction, Pick, Odds for Saturday, September 6

Credit:

Junfu Han / USA TODAY NETWORK via Imagn Images. Pictured: Bryce Underwood (MIchigan)

The Michigan Wolverines take on the Oklahoma Sooners in Norman, OK. Kickoff is set for 7:30 p.m. ET on ABC.

Oklahoma is favored by -4.5 points on the spread with a moneyline of -198. The total is set at 44.5 points.

Here’s my Michigan vs. Oklahoma prediction and college football picks for Saturday, September 6.

Quickslip

Header First Logo
Header Second Logo

Michigan vs Oklahoma Prediction

  • Michigan vs. Oklahoma Pick: 1H Under 21.5 or Better

My Oklahoma vs. Michigan best bet is on the first half under. Find the best line available on our live NCAAF odds page.


Michigan vs Oklahoma Odds

Michigan Logo
Saturday, September 6, 2025
7:30 p.m. EDT
ABC
Oklahoma Logo
Michigan Odds
SpreadTotalMoneyline
+4.5
-105
44.5
-118o / -102u
+164
Oklahoma Odds
SpreadTotalMoneyline
-5.5
-115
44.5
-118o / -102u
-198
Odds via bet365. Get up-to-the-minute NCAAF odds here.
bet365 Logo
  • Michigan vs Oklahoma point spread: Oklahoma -5.5
  • Michigan vs Oklahoma over/under: 46.5 points
  • Michigan vs Oklahoma moneyline: Michigan +164, Oklahoma -198

Header First Logo
Header Second Logo

Michigan vs Oklahoma Preview


Header First Logo

Michigan Wolverines Betting Preview: Newfound Passing Attack

The opening game for freshman phenom Bryce Underwood ended in victory.

Michigan beat New Mexico despite a few hiccups in areas other than the quarterback position.

Underwood completed 21-of-31 passes (with a touchdown) without recording a mistake. Not only did the freshman pass his opening test, the touch on the football in the passing game is new for fans in Ann Arbor.

Michigan needed to replace bundles of production from last year's team, but it produced enough in the opener against the Lobos.

The Wolverines stuffed 11 of 25 New Mexico rushing attempts, limiting the Lobos to just three yards per play.

The havoc of coordinator Wink Martindale carried over from previous season, as the Wolverines generated nine tackles for loss in an opening statement game.


Header First Logo

Oklahoma Sooners Betting Preview: Can Defense Keep it Up?

The preseason steam on quarterback John Mateer's arrival in Norman was peak leading up to kickoff, but the rushing statistics didn't meet the expectation. Mateer evaded a pass rush for a 20 yards scramble, but managed just eight yards on the ground from three designed rushing attempts.

A trio of running backs also had issues creating yards, as Tory Blaylock, Xavier Robinson and Jovantae Barnes forced just three missed tackles on 23 rushing attempts. Those are tepid numbers for a Sooners offense that was expected to dominate Illinois State on the ground.

The Oklahoma defense did come to play, allowing just seven first downs in the first game. Illinois State went 1-for-11 on third down attempts with an average distance of 9.5 yards.

Combined with four tackles for loss and two quarterback hurries, the Sooners ended the opening game allowing a minuscule 3.3 yards per play to Illinois State.


Header First Logo

Michigan vs Oklahoma Pick, Betting Analysis

The struggles of Oklahoma on the ground weren't expected, as Illinois State limited the Sooners to 3.5 yards per play on rushing attempts. Oklahoma produced just one rush (on 31 attempts) that went for more than 12 yards.

Mateer was able to air out the ball in long distance passing downs, generating a 45% success rate with an average of 12 yards per attempt. The Sooners dependency on the arm of Mateer — strictly in passing downs — could be a hindrance in Norman during Week 2.

Michigan running back Justice Haynes averaged 5.8 yards after first contact with three touchdowns against New Mexico, but it'll face one of the best defenses in the nation.

Head coach Brent Venables had led the Sooners to be a dominate team against the inside zone read through last season and in Week 1 against Illinois State.

For Michigan to get into scoring position on possessions beyond the 40-yard line, Underwood will need to shed the stigma of a freshman playing in his first hostile environment.

Pick: 1H Under 21.5 or Better



Michigan vs Oklahoma Betting Trends



Michigan vs Oklahoma Weather


Get the latest coverage on NCAAF Weather.
About the Author
Collin is a senior writer for the Action Network, but serves in various roles behind the scenes as well. As someone who specializes in data visualization of probabilities, power ratings, and head-to-head matchups, Collin’s work within the college football space powers the Action Network’s PRO projections throughout the college football season, and has done so since the birth of the app in 2017. Collin contributes similarly to the college basketball vertical, and his passion for predictive analytics have led him to become a key force in finding betting edges in more niche markets such as professional wrestling and entertainment awards.

Follow Collin Wilson @_Collin1 on Twitter/X.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.