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No. 2 USC hosts Ohio State on Saturday at 7:30 p.m. ET on NBC from the Los Angeles Memorial Coliseum. The Trojans return home after a 24-7 loss at Wisconsin, while Ohio State enters as the road favorite. Our USC vs. Ohio State prediction is Under 51.5 at around -110.
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USC vs. Ohio State Odds
| Market | Ohio State | USC |
|---|---|---|
| Spread | -6.5 (around -117) | +6.5 (around -105) |
| Moneyline | around -245 | around +200 |
| Total | Over 51.5 (around -110) | Under 51.5 (around -110) |
Ohio State opened around a 7.5-point favorite amongst college football odds before the spread moved toward 6.5. The total also dropped from an opener around 54.5 to 51.5, while the Buckeyes' moneyline sits around -245.
USC vs. Ohio State Prediction and Pick
- USC vs. Ohio State prediction: Under 51.5 at around -110
The market has already moved toward a lower-scoring game, and the matchup supports that direction.
USC is coming off a 24-7 loss at Wisconsin in which the offense struggled to create explosive plays. Jayden Maiava threw for 257 yards with two interceptions and took five sacks, while the Trojans finished with negative rushing yardage.
Ohio State has been much stronger defensively. The Buckeyes have consistently limited opposing passing games and enter Saturday with the type of defense that can force USC into long drives instead of quick scores.
There is also uncertainty around the Ohio State offense, which gives the Buckeyes less reason to turn this into a high-tempo road game. A more conservative approach built around defense and field position would work in favor of the Under.
With the total already falling from the mid-50s to 51.5, Under 51.5 at around -110 is the preferred play.
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The bet365 bonus code offer gives eligible new users $200 in Bonus Bets after a qualifying $10 wager, regardless of the result.
For USC vs. Ohio State on Saturday night, our preferred play is Under 51.5 at around -110. USC struggled badly on offense last week, while Ohio State's defense and the falling market total both point toward a lower-scoring game.
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