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Steelers vs. Patriots Odds & Betting Predictions - September 21, 2025

Steelers at Patriots

5:00 pm • CBS
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Pittsburgh Steelers

0-1
@

New England Patriots

4-13

Steelers at Patriots Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Steelers
0-1
N/A
N/A
N/A
Patriots
4-13
N/A
N/A
N/A
location pinSunday 5:00 p.m.
September 21, 2025
Gillette StadiumFoxborough

Steelers vs. Patriots Props

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Steelers vs. Patriots Public Betting Percentages

Away Logo

Steelers

Public

Home Logo

Patriots

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Patriots are 1-4 in their last 5 games.
  • Patriots are 2-2 in their last 5 games against the spread
  • Patriots are 4-4 in their road games against the spread
  • The totals have gone OVER in 2 of Patriots' last 5 games
  • The totals have gone OVER in 7 of Patriots' 8 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Patriots		7-9-13-4-14-4N/A7-9-1
Steelers		11-66-25-45-36-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Patriots		11-67-13-5N/A11-6
Steelers		8-92-66-34-44-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Patriots		4-13N/AN/AN/A4-13
Steelers		10-7N/AN/A5-35-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 5thBUFW 23-16+3 WO 36.5NE +145
Dec 28thLACL 7-40+6 LO 41.5LAC +250
Dec 22nd@BUFL 21-24+14 WU 48BUF +700
Dec 15th@ARIL 17-30+6 LO 46.5ARI +215
Dec 1stINDL 24-25+2.5 WO 41IND +110

Steelers vs. Patriots Injury Updates

Steelers Injuries

  • Robert Woods
    WR

    Woods is questionable with hip

    Questionable

  • Cole Holcomb
    LB

    Holcomb is out with knee

    Out

  • Calvin Anderson
    T

    Anderson is questionable with groin

    Questionable

  • Juan Thornhill
    S

    Thornhill is questionable with calf

    Questionable

  • Esezi Otomewo
    DE

    Otomewo is questionable with calf

    Questionable

  • Dylan Cook
    T

    Cook is out with foot

    Out

  • Roman Wilson
    WR

    Wilson is out with hamstring

    Out

  • Mason McCormick
    OL

    McCormick is questionable with hand

    Questionable

  • Logan Lee
    DE

    Lee is out with calf

    Out

Patriots Injuries

  • Morgan Moses
    T

    Moses is questionable with knee

    Questionable

  • Hunter Henry
    TE

    Henry is out with foot

    Out

  • Jabrill Peppers
    S

    Peppers is out with hamstring

    Out

  • Kyle Dugger
    S

    Dugger is questionable with ankle

    Questionable

  • Anfernee Jennings
    LB

    Jennings is questionable with knee

    Questionable

  • Cole Strange
    G

    Strange is questionable with knee

    Questionable

  • Marcus Jones
    CB

    Jones is out with hip

    Out

  • Jack Gibbens
    LB

    Gibbens is out with ankle

    Out

  • Ben Brown
    C

    Brown is out with concussion

    Out

  • Christian Gonzalez
    CB

    Gonzalez is out with concussion

    Out

  • Alex Austin
    CB

    Austin is questionable with ankle

    Questionable

  • Jaquelin Roy
    DT

    Roy is out with foot

    Out

  • Ja'Lynn Polk
    WR

    Polk is out with shoulder

    Out

See more NFL Injuries Right Arrow
Depth Charts
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Starter2ND3RD4TH
QBJacoby BrissettDrake MayeJoe Milton
RBRhamondre StevensonAntonio GibsonJaMycal HastyTerrell Jennings
WRDeMario DouglasJavon Baker
TEHunter HenryAustin HooperJaheim Bell
LTCaedan WallaceVederian Lowe
LGSidy Sow
CDavid Andrews
RGMike OnwenuLayden Robinson
WLBAnfernee JenningsOshane Ximines
MLBJa'Whaun Bentley
SLBJahlani TavaiChristian Elliss
LCBJonathan JonesMarcellas Dial
SSKyle DuggerMarte MapuBrenden Schooler
FSJabrill PeppersJaylinn HawkinsDell Pettus
RCBChristian GonzalezAlex Austin
PBryce Baringer
HBryce Baringer
PRMarcus JonesDeMario Douglas
KRMarcus JonesAntonio Gibson
LSJoe Cardona
NBMarcus JonesIsaiah Bolden
NTDavon GodchauxJeremiah Pharms
LWRJa'Lynn PolkKayshon Boutte
DEKeion WhiteDeatrich Wise
DTChristian BarmoreDaniel Ekuale
KJoey Slye

Steelers vs. Patriots Odds Comparison

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Steelers at Patriots Team Totals

MatchupOverUnder
Steelers
0-1
N/A
N/A
Patriots
4-13
N/A
N/A