2022 NFL Week 1 Odds and Schedule: Broncos Favored vs. Seahawks In Russell Wilson’s Return to Seattle, More

2022 NFL Week 1 Odds and Schedule: Broncos Favored vs. Seahawks In Russell Wilson’s Return to Seattle, More article feature image

Getty Images. Pictured: Broncos QB Russell Wilson, Seahawks head coach Pete Carroll

  • Week 1 NFL odds are out! We've outlined spreads and totals for all 16 matchups below.
  • The Broncos open as short road favorites against the Seahawks in Russell Wilson's return to Seattle, which will close out opening week.
  • The Bills, meanwhile, will kickoff the season against the defending Super Bowl champion Rams. Find odds for every Week 1 NFL matchup below.

2022 NFL Week 1 Odds

Bills @ Rams(TNF)Bills -152
Saints @ FalconsSaints -3.542
Browns @ PanthersBrowns -443
49ers @ Bears49ers -6.542.5
Steelers @ BengalsBengals -645
Eagles @ LionsEagles -446.5
Colts @ TexansColts -7.544.5
Patriots @ DolphinsDolphins -2.544.5
Ravens @ JetsRavens -445.5
Jaguars @ CommandersCommanders -444.5
Chiefs @ CardinalsChiefs -353
Raiders @ ChargersChargers -452
Packers @ VikingsPackers -1.549
Giants @ TitansTitans -6.544
Buccaneers @ Cowboys(SNF)Buccaneers -2.551
Broncos @ Seahawks(MNF)Broncos -441
Odds via DraftKings as of writing

Russell Wilson to Denver was the blockbuster trade of the offseason, and he'll be dealing with his old team in the first week of the new season as the Broncos travel to Seattle for the week's finale on Monday Night Football.

Wilson and the Broncos are 4-point favorites in that contest.

The reigning Super Bowl champions, the Los Angeles Rams, will kick off their season by playing host to the Buffalo Bills on the opening night edition of Thursday Night Football. The visiting Bills are favored to open the season with a win according to the oddsmakers, as they're listed as 1-point favorites.

Los Angeles' Super Bowl victim, the Cincinnati Bengals, will face off with the Pittsburgh Steelers in Paul Brown Stadium as a 6-point favorite.

Tom Brady and the Tampa Bay Buccaneers will open the season with a trip to Dallas for the other primetime game on Sunday Night Football.

If their matchup is anything like the thrilling season-opener from last year, we're in for a serious treat. In that epic, Brady led a game-winning field goal drive to close out a 31-29 victory. The Bucs are favored by 2.5 and the total is a hefty 51.

Elsewhere in the league, Patrick Mahomes and the Kansas City Chiefs will visit the Arizona Cardinals while reigning MVP Aaron Rodgers and the Green Bay Packers will square off against their division rivals, the Minnesota Vikings.

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