NFL Odds, Picks & Predictions Cheat Sheet for 4 ET Games

NFL Odds, Picks & Predictions Cheat Sheet for 4 ET Games article feature image
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Jake Roth-USA TODAY Sports. Pictured: Russell Wilson

  • Find everything you need for Sunday's late afternoon NFL slate, including odds for Giants-Cowboys and more.

The first wave of Sunday’s NFL Week 1 games are in the books, but it’s not over yet: We still have five late afternoon games (then Sunday Night Football).

You’ll find our staff’s favorite bets, comprehensive guides for all the 4 p.m. ET games and much more below.

All odds above are as of early Sunday and via PointsBet.

NFL Picks

Chargers-Colts and Giants-Cowboys are among our staff’s favorite bets for the first NFL Sunday of the season.

See why these two against-the-spread picks are among their favorites.

NFL Odds, Previews for Late Afternoon Games

Our experts break down the biggest injuries, mismatches and how they’re betting every Sunday game. You can read their previews for al five late afternoon here or click on the following individual ones.

4:05 ET Games

Colts at Chargers (-6.5): Los Angeles moved from a 3- to 6.5-point favorite following Andrew Luck’s retirement. Read whether our experts think Indianapolis is being undervalued.

Bengals at Seahawks (-9.5): Seattle moved from -8 to -9.5 since the market opened. Read whether our experts think the Seahawks can cover this spread.

4:25 ET Games

Giants at Cowboys (-7.5): Ezekiel Elliott will be in uniform on Sunday. Read how our experts think Zeke’s presence will impact this NFC East showdown.

49ers at Buccaneers (-1): The 51-point total is the highest among Sunday’s games. Read whether our experts think there’s value on the over or under.

49ers-Buccaneers-Betting-Odds-Picks
Isaiah J. Downing-USA TODAY Sports. Pictured: Jimmy Garoppolo

Lions (-3) at Cardinals: Will the Kyler Murray era open with an upset at home? Read what our experts think.

NFL Prop Bets

Player props offer tremendous value on the board every week. Here are two we’re eyeing in these five games.

  • Cardinals WR Christian Kirk’s receptions
  • Chargers QB Philip Rivers’ passing touchdowns

See how Mike Randle recommends betting each.

Koerner’s Projected NFL Odds

Sean Koerner, our Director of Predictive Analytics, uses his Power Ratings to project spreads and totals for every Week 1 game. Compare his projections to available odds to find the best bets for the late afternoon games.

NFL Sharp Report

The Week 1 market has been open for months, but pro bettors are hitting the books hard and causing important line moves in the final stretch.

See how they’re betting Colts-Chargers and Lions-Cardinals.

Late money is also hitting Cowboys-Giants. See how pros are moving this NFC East total.

Rovell’s Vegas Report

Darren Rovell spoke to bookmakers across the country about the betting action for season openers. See which games are making the most noise.

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