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NFL Odds & Preseason Betting Predictions For Friday: 2 Picks For Colts at Lions & Steelers at Panthers

NFL Odds & Preseason Betting Predictions For Friday: 2 Picks For Colts at Lions & Steelers at Panthers article feature image

Justin Casterline/Getty Images. Pictured: Jacob Eason

Note: Find our guide to betting Saturday’s games here.

NFL Preseason Odds

Colts at Lions
Colts -2
33.5 (-110/-110)
7 p.m. ET
Eagles at Jets
Jets -5.5
34 (-110/-110)
7:30 p.m. ET
Steelers at Panthers
Panthers -4
35.5 (-110/-110)
7:30 p.m. ET
Vikings at Chiefs
Chiefs -4.5
38.5 (-110/-110)
8 p.m. ET
Odds as of 1 p.m. ET on Friday and via PointsBet

The dress rehearsal is almost over.

The 2021 NFL preseason ends with a three-day stretch of games, starting with a slate of four this Friday night. Find odds for each matchup above, complete with a spread pick and a first-half angle from our analysts below.

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NFL Preseason Picks

Colts -2 at Lions
Panthers 1H -3.5 (-110) vs. Steelers

Colts -2 at Lions

Raheem Palmer: Betting preseason football is about two things: Information and depth.

No complex models necessary, no emphasis on matchups or advanced game plans. It’s all information-based, and fortunately for us, head coaches tend to let us know their plan for playing their starters. Well, the Colts aren’t playing most of theirs, while the Lions aren’t playing any of their first-team guys. That means no Jared Goff, D’Andre Swift, Jamaal Williams, Tyrell Williams or T.J Hockenson. No Taylor Decker or Frank Ragnow. Key defensive players will also be missing in action.

While the Colts aren’t playing most of their starters, Jacob Eason and Sam Ehlinger will still be battling it out for the No. 2 quarterback position. And given the health concerns of Carson Wentz, you have to expect the best from both guys. Ehlinger should get a ton of time — he’s shown he’s more than capable after directing a game winning drive in the Colts’ preseason opener.

The Lions are shaping up to be one of the worst teams in the NFL this season, and I trust the depth of the Colts. Lay the two points with Indianapolis.

Panthers 1H -3.5 (-110) vs. Steelers

Editor’s note: We updated this pick at 2:45 p.m. ET to reflect the latest availability in the market.

Sean Koerner: The Panthers have bubble-wrapped Sam Darnold and most of their starters so far this preseason, but they plan on playing most of them for the first half on Friday night. Meanwhile, the Steelers played in the Hall of Fame Game, meaning they’re playing one extra preseason game this year and plan on resting all starters.

I like attacking this mis-matched first half and backing the Panthers.

Be sure to follow me in the Action app for any potential live bets — most of my preseason action has been in-game, leveraging my knowledge of the personnel rotations from setting up player projections.

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