Our football staff is focused on seven of Sunday's biggest games for our NFL predictions in Week 6 on October 12.
First, we'll focus on Seahawks vs Jaguars and Rams vs Ravens in the early window. Later in the afternoon, we have a pair of predictions for Titans vs Raiders and Buccaneers vs 49ers. We also have picks for Cowboys vs. Panthers, Patriots vs Saints, and more.
Let's dive into our expert NFL picks and best bets for the Week 6 Sunday slate.
NFL Predictions & Picks — Week 6
| Game | Time (ET) | Pick |
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  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 4:05 p.m. | |
  | 4:25 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Seahawks vs Jaguars Moneyline Best Bet
The Seahawks were the latest team to suffer at the hands of Baker Mayfield and the Buccaneers.
Despite tallying another loss last week, there is plenty for Seahawks fans to be excited about.
The Seahawks posted an impressive 86.7% series success rate against the Bucs, and Sam Darnold averaged 0.6 EPA per play and a 16.3% completion percentage over expected — two impressive marks.
You could also make the argument that Jacksonville got outplayed on Monday Night Football.
Kansas City had a higher success rate, and Jacksonville was the beneficiary of a pick-6 early in the second half.
I will bet on the regression train to even things out for both of these teams, and Seattle comes out on top.
Pick: Seahawks Moneyline (-105)
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Rams vs Ravens ATS Pick
By Brit Devine
The Ravens look like they will be without Lamar Jackson in this game, and based off of Wednesday's practice report, they could be waving the white flag already, with a bunch of key defensive players not practicing to start the week.
The Ravens have a bye next week, and the only way to save the season would be for them to come back off the bye as healthy as possible and start putting up wins with Jackson back.
I'm speculating a little here, but I expect the Ravens to keep anyone who isn't fully healthy out for this game, which would mean not only an offense that is extremely limited, but a defense that is missing so many key players that they may be fielding the worst defensive unit in football.
The Rams should be able to steamroll the Ravens.
Pick: Rams -7.5 (-110)
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Cowboys vs Panthers Total Prediction
By Bet Labs
The system titled "High Winds" is an NFL system built on how weather directly impacts offensive efficiency and scoring potential.
When average wind speeds climb into the double digits, passing games struggle with accuracy, kicking becomes unreliable, and play calling leans more heavily toward conservative runs.
This naturally limits explosive plays and lowers scoring opportunities, which appears to be the situation in this week's matchup between the Cowboys and Panthers.
With temperatures sitting in a reasonable range that does not drastically impact player stamina or ball handling, wind becomes the defining variable.
Both regular season and postseason games fit this mold, as weather remains an equalizer regardless of stakes.
Betting the under in these conditions takes advantage of how the market often undervalues the true effect of sustained wind on football outcomes.
Pick: Under 49.5 (-115)
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Patriots vs Saints Spread Prediction
By Dylan Wilkerson
Last week, Spencer Rattler secured his first NFL win for the Saints, and I think he secures another this week.
One of my favorite metrics to use when betting the NFL is Action Network's Luck Rankings. Nick Giffen crafted this metric to help filter out noise in any given NFL game.
According to his metrics, the Patriots are the ninth-luckiest team in the NFL, whereas the Saints are currently 25th.
I am going to bet on some luck regression hitting both of these teams and bank on the Saints to keep it close.
Pick: Saints +3.5 (-110)
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Titans vs Raiders ATS Best Bet
By Bet Labs
The system titled "Small Bad Away 'Dogs" captures how NFL teams often exceed expectations when the spread is modest, whenever they play poor the previous season, and then enter the new year as underdogs on the road.
Teams with few wins from the prior year are usually overlooked by both oddsmakers and bettors, yet these squads can show meaningful improvement with roster changes, draft additions, or coaching adjustments.
Being priced as small underdogs rather than large ones suggests the market already sees potential, but not enough to account for the motivational edge and element of surprise that these teams often bring.
Playing in the regular season, when effort is high and opportunities to reset the narrative are strongest, creates a profitable window where small underdogs with bad histories prove to be undervalued and capable of covering spreads consistently.
Pick: Titans +4.5 (-110)
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Buccaneers vs 49ers Spread Prediction
By Dylan Wilkerson
There is no doubt that Baker Mayfield has been amazing this season. We are through five weeks and Baker has led the Buccaneers to victories with four game-winning drives.
Conversely, Mac Jones has been more than serviceable in his time as the 49ers' starter in Brock Purdy's absence.
It is unclear if Jones or Purdy will start for the 49ers this week, but I am not sure if that decision means much at this point.
Tristan Wirfs has allowed an 11.1% pressure rate in the two games since his return from injury, about 2.5x higher than his career average heading into the season.
If this is a reliable data point, the 49ers' pass rush could attack a weaker than normal Wirfs and get to Mayfield.
I like San Francisco to keep this one close.
Pick: 49ers +3 (-110)
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