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NFL Week 2 Odds, Picks, Predictions for All 12 Sunday Afternoon Games

NFL Week 2 Odds, Picks, Predictions for All 12 Sunday Afternoon Games article feature image
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Sam Greenwood/Getty Images. Pictured: Kyler Murray.

Week 2 NFL Odds, Picks

Click on a matchup to skip to that matchup preview and pick.
Colts vs. Jaguars
1 p.m. ET
Dolphins vs. Ravens
1 p.m. ET
Jets vs. Browns
1 p.m. ET
Buccaneers vs. Saints
1 p.m. ET
Patriots vs. Steelers
1 p.m. ET
Panthers vs. Giants
1 p.m. ET
Commanders vs. Lions
1 p.m. ET
Seahawks vs. 49ers
4:05 p.m. ET
Falcons vs. Rams
4:05 p.m. ET
Cardinals vs. Raiders
4:25 p.m. ET
Texans vs. Broncos
4:25 p.m. ET
Bengals vs. Cowboys
4:25 p.m. ET
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Colts Odds -3
Jaguars Odds +3
Moneyline -168 / +142
Over/Under 45.5
Time Sunday, 1 p.m. ET
TV CBS
Odds via FanDuel. For the latest odds“>NFL odds, click here.

Sam Farley: The best receiving prop around for this game sits with the Jaguars’ new acquisition: Christian Kirk.

The former Texas A&M player endured a slow start to last week’s game, but by the end it was clear that he’s the key receiver on this offense, having been targeted 12 times.

Kirk played 51 of his 64 snaps from the slot and went off, converting his six catches into 117 yards. He was also third across the NFL for Air Yards with 128, behind just Davante Adams and Brandin Cooks.

That same Cooks faced this Colts secondary last week and had a big day himself, getting 82 yards with 131 Air Yards. Now Kirk faces that same defense, coming off a day in which he played 91% of snaps and is likely to have a game script favoring passing with the Jags likely to play from behind. You’ve got to play the Over on Kirk receiving yards when all the data is telling you that it’s the best play.

Pick: Christian Kirk Over 58.5 Receiving Yards | Bet to 62.5

Read the full Colts vs. Jaguars preview or return to the table of contents

Dolphins Odds +3.5
Ravens Odds -3.5
Moneyline +160 / -190
Over/Under 44.5
Time Sunday, 1 p.m. ET
TV CBS
Odds via FanDuel. For the latest NFL odds, click here.

Landon Silinsky: We saw Miami’s defense have success both last season and in last week’s opener, but Jackson is not Mac Jones. The dual-threat QB is playing for a new contract and I expect him to show off his skills as a pocket passer this season.

Having said that, the loss of Fuller hurts and if Humphrey also misses this contest, the Dolphins will have a massive edge in the passing game, specifically the short game with Hill and Waddle.

The Ravens allowed the 12th-highest catch rate in the NFL to wide receivers last week, and now they’re even thinner in the secondary. McDaniel appears to know how to exploit weaknesses, so I will take the points with Miami in this one.

Pick: Dolphins +3.5 | Bet to 3

Read the full Dolphins vs. Ravens preview or return to the table of contents
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Jets vs.

Browns

Jets Odds +6.5
Browns Odds -6.5
Moneyline +220 / -270
Over/Under 39.5
Time Sunday, 1 p.m. ET
TV CBS
Odds via FanDuel. For the latest NFL odds, click here.

The Great Foosini: This is a classic case where the final score of two games does not tell the full story. We see one team who put up 26 points and beat an AFC foe on the road, and one who lost by 15 while not covering the spread.

Digging in further reveals that these results were not truly reflective of the underlying yards-per-play statistics, and the expected outcome is much different than the actual one.

What do the Jets and Browns have in common coming out of Week 1? Yards per play.

You have one squad at 4.8 and another with 4.8, but one is laying 6.5 points? That does not make a ton of sense.

While the Jets will always be the Jets, this is one opportunity where the points become incredibly valuable.

Give me the Jets on the road with Joe Flacco against the Jacoby Brissett-led Browns. It won’t be a pretty contest, but I have this closer to a field goal than I do almost a touchdown. Prayers up.

Pick: Jets +6.5 | Bet to 5.5 (-110)

Read the full Jets vs. Browns preview or return to the table of contents

Buccaneers Odds -2.5
Saints Odds +2.5
Moneyline -144 / +122
Over/Under 43.5
Time Sunday, 1 p.m. ET
TV FOX
Odds via FanDuel. For the latest NFL odds, click here.

Cody Goggin: In the end, I think that the hopes of the Saints being able to completely shut out Brady again aren’t realistic. New Orleans’ defense may be OK, but with the turnover in the secondary and how they looked against the Falcons last week, I’m going to rely on that information this week and side with them being a touch overrated.

When the final injury reports come out, I would expect that this line will move to -3. That’s why I want to get this line at -2.5 if possible and stay within that key number. You could still take this at -3 if the injury report contains good news for the Buccaneers and you still love the bet, but I would definitely not play -3.5 if it goes that far.

FanDuel Quickslip: Buccaneers -2.5 | Bet to -3 pending injury report

Read the full Buccaneers vs. Saints preview or return to the table of contents

Patriots Odds -2.5
Steelers Odds +2.5
Moneyline -142 / +120
Over/Under 40.5
Time Sunday, 1 p.m. ET
TV CBS
Odds via FanDuel. For the latest NFL odds, click here.

Phillip Kall: Last week, the Steelers played a nearly perfect game defensively and were lucky to walk away with a win. This week they will try to recreate that magic without one of the best defensive players in the league. The Patriots will also be playing a much more conservative style, leaving fewer opportunities for Pittsburgh to make game-swinging plays. 

That will leave the pressure on the Steelers offense to make things happen. The good news is that it may only need one or two good drives to outscore the Patriots. The bad news is that they will be doing so against a Bill Belichick defense.

One of the regular themes in an NFL game is the Patriots forcing you to win with your off-hand. In this case, that will be forcing the Steelers to throw the ball outside. Last week the Steelers receivers had just 3.5 yards per target on their 22 opportunities.

With the Steelers offense hampered, the Patriots should feel no pressure on defense. This will allow them to stick with their game plan and play a run-first, ball-control offense. On the only scoring drive against Miami, we saw them play this way it ended in a touchdown. The drive took nearly eight and a half minutes but given their limited receiving core and quarterback it’s their path to victory. 

Trust the Patriots to lean on their defense and ground and pound their path to victory. This should be a close one given the nature of the game. If you have to lay more than a field goal stay away.

FanDuel Quickslip: Patriots -2.5 | Bet to -3

Read the full Patriots vs. Steelers preview or return to the table of contents

Panthers Odds +1.5
Giants Odds -1.5
Moneyline +108 / -126
Over/Under 43.5
Time Sunday, 1 p.m. ET
TV FOX
Odds via FanDuel. For the latest NFL odds, click here.

Dylan Wilkerson: Both of these teams have issues moving the ball, but when they do get some momentum going, it usually comes late.

Dating back to last season, Panthers first quarter totals have gone under nine points 11 times. The Giants’ first-quarter totals have gone under nine points 13 times.

Suffice to say we should expect to see a slow start to this game.

It is important to note that FanDuel has the best number for this play at 9, but I would play it at 7.5, which is what the first-quarter total is at DraftKings and Caesars.

Pick: 1Q Under 9 | Bet to 7.5

Read the full Panthers vs. Giants preview or return to the table of contents

Commanders Odds +1
Lions Odds -1
Moneyline +100 / -118
Over/Under 48.5
Time Sunday, 1 p.m. ET
TV FOX
Odds via FanDuel. For the latest NFL odds, click here.

Kody Malstrom: It’s been a long time — 2020, to be specific — since the Lions have been favored at kickoff, and for good reason. They’ve been a laughingstock of a team known for late-game meltdowns and generally embarrassing performances. 

But this team feels different.

Detroit’s offense checked all the boxes I was looking for against the Eagles. Washington’s offense was a mess against the Jags, although the score didn’t reflect it. Losing out in most metrics, this team has some serious flaws. Now, the Commanders defense faces a tougher test.

Should the Lions’ defensive line generate any sort of pressure to ease the load of the secondary, I believe it may be too much for the Commanders to overcome.

FanDuel Quickslip: Lions -1.5 | Bet to 2.5

Read the full Commanders vs. Lions preview or return to the table of contents

Seahawks Odds +9.5
49ers Odds -9.5
Moneyline +320 / -405
Over/Under 40.5
Time Sunday, 4:05 p.m. ET
TV FOX
Odds via FanDuel. For the latest NFL odds, click here.

Blake Krass: Going against public perception after one game is a good way to win. On top of that, the 49ers lost a game in bizarre weather conditions, while the Seahawks won a game in which they were easily outplayed. That sets up a perfect bounce-back spot for San Francisco.

I think the value is on the 49ers to cover this single-digit spread. Their defense should give Smith issues, and Lance should be able to operate the offense smoothly at home.

I am rolling with the 49ers at -9 and would play them up to 10. I think there is a clear edge defensively for San Francisco, which should dominate.

Pick: 49ers -9 | Bet to -10

Read the full Seahawks vs. 49ers preview or return to the table of contents

Falcons Odds +10
Rams Odds -10
Moneyline +410 / -550
Over/Under 46.5
Time Sunday, 4:05 p.m. ET
TV FOX
Odds via FanDuel. For the latest NFL odds, click here.

Landon Silinsky: We have a pretty clear get-right spot for the defending Super Bowl champs. I expect the Rams not only to feature Kupp, but also to get Allen Robinson involved early and often after he was erased by Buffalo’s defensive scheme.

This is a clear mismatch on both sides of the ball and I will lay the points with the Rams here. I just don’t see the Falcons being able to generate much offense against Aaron Donald, Jalen Ramsey and Co.

FanDuel Quickslip: Rams -10 | Bet to -11

Read the full Falcons vs. Rams preview or return to the table of contents

Cardinals Odds +5.5
Raiders Odds -5.5
Moneyline +190 / -230
Over/Under 51.5
Time Sunday, 4:25 p.m. ET
TV CBS
Odds via FanDuel. For the latest NFL odds, click here.

John LanFranca: The Chiefs and Raiders should not, under any circumstances, both carry a 5.5-point advantage into a game against the Cardinals. 

Las Vegas’ offense graded out 29th in the league according to Football Outsiders’ DVOA metric in Week 1. Derek Carr earned a corresponding PFF grade, finishing 31st of 32 qualifying quarterbacks.

This line flirted with six before sharp money drove it back down to 5.5. The Cardinals are a live dog in this situation and have proven time and time again they flourish in the road underdog role.

I will gladly fade the Raiders in this spot and grab the value with points and the Arizona moneyline.

Picks: Cardinals +5.5 & +200 moneyline (BetMGM) | Bet to +5 & +185

Read the full Cardinals vs. Raiders preview or return to the table of contents

Texans Odds +10
Broncos Odds -10
Moneyline +360 / -460
Over/Under 45.5
Time Sunday, 4:25 p.m. ET
TV CBS
Odds via FanDuel. For the latest NFL odds, click here.

John LanFranca: The Broncos were first in the NFL in time of possession per drive on offense. Their defense will be lathered up for their home opener.

Where the Broncos excel on defense can limit the Texans’ offense and force Mills to be uncomfortable. There won’t be many possessions in this game, as the Broncos have no reason to deviate from their 29th-ranked neutral offensive pace.

It all adds up to a strong play on the under.

FanDuel Quickslip: Under 45.5 | Bet to 45

Read the full Texans vs. Broncos preview or return to the table of contents

Bengals Odds -7.5
Cowboys Odds +7.5
Moneyline -340 / +275
Over/Under 41.5
Time Sunday, 4:25 p.m. ET
TV CBS
Odds via FanDuel. For the latest NFL odds, click here.

Anthony Dabbundo: Any time an NFL line moves nine points from the lookahead the week prior, you should absolutely be skeptical of that.

What do we truly know that’s different about either of these two teams? Dallas played one of the best defenses in the NFL and had a bad game, while Cincinnati did exactly the same.

I don’t expect the Bengals to turn it over five times again, but let’s not pretend that Cincinnati was moving the ball at will. The Bengals had 4.6 yards per play and only cleared 400 yards of offense because they ran 94 plays.

There’s a well-documented history of defending Super Bowl losers struggling to begin the following season. Look no further than the last three years, when the Rams, 49ers and Chiefs struggled out of the gates.

The market has absolutely loved Cincinnati, but the Steelers defense made it a point to take away the deep boundary throws to Chase, and I’m sure defensive coordinators will take notice of that.

Even though Rush has only made one career start, he did post a positive but below league average EPA per play in that game.

Like we do so often in the NFL, it’s time to hold your nose and bet Dallas catching more than a touchdown at home.

FanDuel Quickslip: Dallas +7.5 | Bet to +7

Read the full Bengals vs. Cowboys preview or return to the table of contents

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