Seahawks vs 49ers Picks, Predictions: NFL Week 2 Preview

Seahawks vs 49ers Picks, Predictions: NFL Week 2 Preview article feature image

Photo by Michael Reaves/Getty Images. Pictured: Trey Lance (center).

  • The 49ers are 8.5-point favorites today against the Seahawks.
  • San Francisco lost its opener in Chicago, while Seattle pulled off an upset on Monday Night Football.
  • Check out Blake Krass' game preview and how he's betting the game below.

Seahawks vs. 49ers Odds

Sunday, Sept. 18
4:05 p.m. ET
Seahawks Odds
-110o / -110u
49ers Odds
-110o / -110u
Odds via BetMGM. Get up-to-the-minute NFL odds here.

This is a classic NFL Week 2 matchup.

The trendy 49ers lost outright to the Bears in Week 1 as big favorites. On the other side, the Seahawks were big underdogs against old friend Russell Wilson, but Geno Smith stepped up to help Seattle win a massive game in primetime.

Now, people are much lower on the 49ers and much higher on the Seahawks based on a tiny sample size. For us, that creates value on the 49ers as they open their home campaign as single-digit favorites against their division rivals.

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Seahawks vs. 49ers Matchup Analysis

Toggle the dropdowns below to hide or show how the Seahawks and 49ers match up statistically:

Seahawks vs. 49ers DVOA Breakdown
Overall DVOA215
Pass DVOA129
Rush DVOA2211
Overall DVOA2823
Pass DVOA2927
Rush DVOA133

Despite the Seahawks pulling off the upset and the 49ers falling to the Bears, San Francisco is actually ranked higher in overall DVOA after Week 1.

It's hard to take much away from the 49ers' first game since it was played in a swamp inside Soldier Field. Trey Lance should be much more comfortable at home against a Seattle defense that ranks 23rd in defensive DVOA.

The Broncos actually out-gained the Seahawks 433 to 253 last week. Denver couldn't score in the red zone and had some bizarre coaching decisions. That should not be an issue for Kyle Shanahan's offense, which was fourth in the league in red zone scoring percentage (64.41%) last season.

Betting Picks

Going against public perception after one game is a good way to win. On top of that, the 49ers lost a game in bizarre weather conditions, while the Seahawks won a game in which they were easily outplayed. That sets up a perfect bounce-back spot for San Francisco.

I think the value is on the 49ers to cover this single-digit spread. Their defense should give Smith issues, and Lance should be able to operate the offense smoothly at home.

I am rolling with the 49ers at -9 and would play them up to 10. I think there is a clear edge defensively for San Francisco, which should dominate.

Pick: 49ers -9 | Bet to -10

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