NFL Week 6 Odds for All 14 Games

Week 6 NFL Odds

All odds as of 7:30 p.m. ET on Sunday night.

Commanders vs.

Bears

It can't get any worse than last week's Colts-Broncos matchup, right? Well, the Commanders and Bears will certainly test that. Washington has lost four straight games, while Chicago has dropped back-to-back contests.

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Jaguars vs.

Colts

Neither the Colts or Jaguars looked good on offense, and both played well defensively in Week 5. The difference is that Indianapolis won in Denver, while Jacksonville inexplicably lost at home against the Texans.

Jets vs.

Packers

In past years, the Jets would be just what the doctor ordered after a loss in London like the Packers suffered. These aren't your normal Jets, though. New York is 3-2 and looking good with young playmakers flanking Zach Wilson.

Ravens vs.

Giants

This line was released before the Ravens faced Cincinnati on Sunday Night Football. The Giants are 3-2 and coming off an upset win in London against the Packers.

Bengals vs.

Saints

This line was released before the Bengals played on Sunday Night Football. The Saints will welcome Joe Burrow back to Louisiana coming off a rejuvenated offensive performance against the Seahawks, led by Taysom Hill.

Buccaneers vs.

Steelers

The Buccaneers rebounded from back-to-back losses in relatively unconvincing fashion against the Falcons. They'll hope to feast on Kenny Pickett in his second career start after a shellacking in Buffalo.

49ers vs.

Falcons

The 2022 Atlanta Falcons are still undefeated against the spread after a late cover against the Buccaneers. The 49ers defense will be a stiff test, though.

Patriots vs.

Browns

Bailey Zappe looked more than capable of leading the Patriots offense, although that was against an awful Lions defense. A trip to Cleveland will provide a much better test.

Vikings vs.

Dolphins

There's no telling who's going to be under center for Miami after Tua Tagovailoa's well-publicized head injuries and Teddy Bridgewater left Week 5 very early.

Panthers vs.

Rams

After losing to Jimmy Garoppolo and Cooper Rush, maybe the Rams can finally beat Baker Mayfield, who looks lost as he runs out of time as a starting QB in the NFL.

Cardinals vs.

Seahawks

The Seahawks lost in New Orleans, but their offense looks legit. A matchup with Kyler Murray should create fireworks.

Bills vs.

Chiefs

The best matchup of the season — so far. A rematch of the epic playoff game last January in Kansas City will no doubt be memorable. Buffalo, the Super Bowl favorites, open as favorites ahead of the Chiefs' Monday Night Football game against the Raiders.

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Cowboys vs.

Eagles

Will Dak Prescott return, or will the 4-0 Cooper Rush get a chance to give the Eagles their first loss of the season? Philadelphia is unsurprisingly favored.

Broncos vs.

Chargers

More Broncos in primetime? OK, fine. Denver will have to keep up with a Chargers offense that is showing signs of life, and that's without Keenan Allen.