Seahawks vs. 49ers Odds, Picks & Monday Night Football Cheat Sheet

Seahawks at 49ers Odds, Picks & Predictions

• Odds: 49ers -6
• Over/Under: 47
• Kickoff: 8:15 p.m. ET
• TV Channel: ESPN

Odds as of 3:30 p.m. ET on Monday and via PointsBet, where Action Network users can access an exclusive promotion to get a 200% deposit match (deposit $50, bet with $150).

Monday Night Football Betting Guide

Our analysts and experts break down the most important angles of this game.

Here's an excerpt, but you can read the full story here.

One of the reasons the 49ers have been so dominant is because of their defensive line, which features four former first-round picks in Nick Bosa (2019), DeForrest Buckner (2016), Arik Armstead (2015) and ex-Chief Dee Ford (2014).

All four grade out top 12 at their position from Pro Football Focus, with Bosa, Ford and Armstead in the top eight.

And while you wouldn’t necessarily know it thanks to Russell Wilson’s brilliance, but Seattle’s offensive line has struggled this season. Per Football Outsides, the Seahawks are ranked 30th in adjusted sack rate (7.5%) while the 49ers swarming unit leads the league in that metric.

Read our full betting breakdown for Seahawks-49ers.

Our Staff's Seahawks vs. 49ers Picks

The public is buying the Seahawks as 6-point underdogs, but is that where the best value is? Our staff reveals how they're betting this game.

An Over/Under Betting System

Casual bettors are expecting a shootout in Santa Clara, but history says they could be disappointed. John Ewing on a profitable system for betting this total.

Best Prop Bet

With George Kittle (knee) listed as doubtful, Ross Dwelley is expected to step in at tight end for the 49ers. Here's how to bet his receptions prop.

Monday Night Miracle Odds

Need 20 points from Tevin Coleman to win your Week 10 fantasy matchup? He has a 10.70% chance of pulling out a Monday night miracle for you. Sean Koerner calculates the chances of key players getting you a win.

DFS Showdown Slate

Cash game strategy. Core GPP plays. Stacks. Chris Raybon breaks down how to play the single-game slate.