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Canadiens vs. Flames Prediction, Pick, Odds for Wednesday (October 22)

Canadiens vs. Flames Prediction, Pick, Odds for Wednesday (October 22) article feature image
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The Montreal Canadiens (5-2-0) and Calgary Flames (1-6-0) meet in the NHL tonight. Puck drop is set for 8:30 p.m. EDT at Scotiabank Saddledome in Calgary, AB. The game will be broadcast live on ESPN+.

The Canadiens are favored by -1.5 on the puck line, with the over/under set at 5.5 (-127o / +107u). The Canadiens are a -125 favorite to win outright, while the Flames are +105 to pull off the upset.

Let's get into my Canadiens vs. Flames predictions and NHL picks.

Canadiens vs. Flames Odds, Pick

Canadiens Logo
Wednesday, October 22, 2025
8:30 p.m. EDT
ESPN+
Flames Logo
Canadiens Odds
SpreadTotalMoneyline
-1.5
+192
5.5
-127o / +107u
-125
Flames Odds
SpreadTotalMoneyline
+1.5
-235
5.5
-127o / +107u
+105
Odds via bet365. Get up-to-the-minute NHL odds here.
bet365 Logo

Canadiens vs. Flames Spread: Canadiens -1.5 (+192), Flames +1.5 (-235)

Canadiens vs. Flames Over/Under: 5.5 (-127o / +107u)

Canadiens vs. Flames Moneyline: Canadiens -125, Flames +105

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Canadiens vs. Flames Prediction, Pick

Our "Fade Home 'Dog off Loss at Home" NHL moneyline betting system focuses on situations where a team is at home as an underdog after dropping its last game in that same building by a narrow margin.

While it might appear that home ice and recent motivation create value, these spots often expose deeper issues. A team priced as an underdog at home after a recent home defeat usually signals lack of market trust in their roster, goaltending, or form, and the emotional lift of playing at home does not offset those gaps. Oddsmakers expect the losing trend to continue, and public bettors often overestimate bounce back potential, making it more profitable to fade these clubs despite their home setting.

Overall, this system is 873-564 (61%) and has generated a 3% ROI. This season, the system is off to a fast start, going 7-3 and producing a 17% ROI.

Best Bet: Canadiens Moneyline

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