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Chicago Blackhawks vs Buffalo Sabres NHL Prediction, Pick, Odds, November 21

Chicago Blackhawks vs Buffalo Sabres NHL Prediction, Pick, Odds, November 21 article feature image
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Kamil Krzaczynski-Imagn Images. Pictured: Connor Bedard

The Chicago Blackhawks (10-6-4) and Buffalo Sabres (7-9-4) meet in the NHL tonight. Puck drop is set for 7:00 p.m. EST at KeyBank Center in Buffalo, N.Y. The game will be broadcast live on ESPN+.

The Sabres are favored by -1.5 on the puck line, with the over/under set at 6 (-120o / +100u). The Sabres are a -190 favorite to win outright, while the Blackhawks are +160 to pull off the upset.

Let's get into my Blackhawks vs. Sabres predictions and NHL picks.

Blackhawks vs. Sabres Odds, Pick

Blackhawks Logo
Friday, Nov 21
7 p.m. ET
ESPN+
Sabres Logo
Blackhawks Odds
SpreadTotalMoneyline
+1.5
-155
6
-120o / 100u
+160
Sabres Odds
SpreadTotalMoneyline
-1.5
+130
6
-120o / 100u
-190
Odds via bet365. Get up-to-the-minute NHL odds here.
bet365 Logo

Blackhawks vs. Sabres Spread: Sabres -1.5 (+130), Blackhawks +1.5 (-155)

Blackhawks vs. Sabres Over/Under: 6 (-120o / +100u)

Blackhawks vs. Sabres Moneyline: Blackhawks +160, Sabres -190

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Blackhawks vs. Sabres Preview

After four straight home games, the Chicago Blackhawks will hit the road again tonight, visiting Buffalo.

The Sabres are dead last in the Eastern Conference with a 7-9-4 record, but show up as favorites tonight, given their much better performance at home (6-4-2) than away (1-5-2).

Chicago will not be intimidated by that, as they have identical positive splits (5-3-2) on the road and at home.

The most interesting fact, however, is their away streak. Before their recent homestand, the Blackhawks won their last three games on the road, all of them by a comfortable margin. They beat the Canucks 5-2, the Flames 4-0 and the Red Wings 5-1.

Tonight against the Sabres, Chicago will hope to make it four in a row, spearheaded by their 20-year-old star Connor Bedard, who leads the team in points (29) and goals (13) this season.

Our Bet Labs system recommends backing the underdogs at a great value.


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Blackhawks vs. Sabres Prediction

The Home to Road Dogs system focuses on NHL teams that begin a road stretch immediately after playing at home, catching oddsmakers and the public off guard.

These teams, now labeled as underdogs, often benefit from early travel energy and a renewed focus after leaving the distractions of home.

In the early part of the season, motivation runs high as players look to establish rhythm and identity, leading to sharper performances than their moneyline suggests.

The public tends to overvalue home teams in these matchups, driving value toward the visiting side.

When a team transitions from home to road early in the year, the combination of market bias and competitive urgency creates profitable opportunities on overlooked road dogs.

Best Bet: Blackhawks ML +160 (bet365)

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